Cyr61和VEGF在慢性髓细胞白血病中的表达及相关性探讨.pdf

《Cyr61和VEGF在慢性髓细胞白血病中的表达及相关性探讨.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、·354·JournalofClinicalHematology，Jul2009，Vol22No7Cyr61和VEGF在慢性髓细胞白血病中的表达及相关性探讨王志敏丛雅琴马立宁胡晓静阎树昕林庆国。[摘要]目的：探讨富半胱氨酸61(Cyr61)基因蛋白在慢性髓细胞白血病(CML)中的表达及其与血管内皮细胞生长因子(VEGF)基因表达的相关性。方法：应用免疫组织化学SP法检测4o例CML患者及1O例正常对照组骨髓单个核细胞中Cyr61、VEGF蛋白的表达，分析其与CML的发生、发展的关系及2者的相关性。结果：①CM

2、L患者在慢性期、加速期、急变期骨髓单个核细胞中Cyr61和VEGF蛋白表达水平明显高于正常对照组(P

3、CML的发生、发展及预后有关，且2者存在一定的相关性。[关键词]白血病，慢性，髓细胞性；富含半胱氨酸61；血管内皮细胞生长因子[中图分类号]R733．72[文献标志码]A[文章编号]10042806(2009)07—0354—03ExpressionsofCyr61andVEGFinhumanchronicmyeloidleukemiaandtheirassociativityWANGZhiminCONGYaqinMALiningHUXiaojingYANShuxinL，NQingguo(Department

4、ofHematology，QiluHospitalofShandongUniversity，Jinan，250012，Chi—na；DepartmentofManagement，ShandongUniversityofTraditionalChineseMedicine)AbstractObjective：Toexploretheexpressionsofcysteinerich61(Cyr61)andVEGFproteinandtheircorre—lationinhumanchronicmyeloidle

5、ukemia(CML)．Method：ExpressionsofCyr61andVEGFproteinweredetectedinbonemarrowmononuclearcell(BMMNC)from40patientswithCMLand10normalcontrolsbyimmunohisto—chemicalmethod．Result：①ExpressionsofCyr61andVEGFproteininchronicphase，acceleratedphaseandblastcrisisweresi

6、gnificantlyhigherinCMIpatientsthaninnormalcontrols(P<0．05)．ExpressionsofCyr61andVEGFproteinwerehigherinacceleratedphaseandblastcrisisthaninchronicphase(P

7、ientswithoutabnormalkaryotype(P

8、sofCyr61andVEGFproteinmayberelatedtOtheprogression，genesisandprognosisofCMLpatients．Keywordsleukemia，chronic，myetogenous；cysteinerich61；vascularendothelialgrowthfactor慢性髓细胞白血病(chronicmyeloidleukemi—现，C