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1、第26卷第3期西安交通大学学报(医学版)Vol.26No.32005年6月JournalofXipanJiaotongUniversity(MedicalSciences)Jun.2005西安地区小儿非细菌性肺炎的病原学检测与分析12111刘志刚,王亚超,张崴,罗树舫,邹爱萍(1.西安交通大学第一医院儿科,陕西西安710061;2.咸阳市第一人民医院儿科,陕西咸阳721000)摘要:目的了解西安地区小儿非细菌性肺炎的病原学特点。方法应用固相ELISA技术检测病毒IgM抗体及金标免疫斑点法检测肺炎支原体IgM抗体。结果共检测302例肺炎患儿,测得肺炎支原体和(或)病毒阳性者204例,感染总阳性
2、率为67.55%(204/302),共测出病原阳性株328株,其中肺炎支原体(MP)120株(36.6%),柯萨奇病毒(CV)77株(23.5%),呼吸道合胞病毒(RSV)56株(17.1%),流感病毒39株(11.9%),腺病毒25株(7.6%),EB病毒(EBV)11株(3.4%)。单一感染为51.99%(157/302),混合感染为15.56%(47/302);西安地区一年四季各种病原体发生率有显著性差异(P<0.05);各年龄段间病原体比较,没有显著性差异(P>0.05),但以7个月～3岁小儿发病率最高。结论MP、CV、RSV是西安地区小儿非细菌性肺炎的主要病原。关键词:儿童;肺炎;
3、病原学中图分类号:R725.6文献标识码:A文章编号:167128259(2005)0320250203Thedetectionandanalysisofetiologyofnon2bacterialpneumoniainchildreninXipan12111LiuZhigang,WangYachao,ZhangWei,LuoSufang,ZouAiping(1.DepartmentofPediatrics,FirstHospitalofXipanJiaotongUniversity,Xipan710061;2.DepartmentofPediatrics,FirstPeoplepsHos
4、pitalofXianyangCity,Xianyang721000,China)ABSTRACT:ObjectiveToinvestigatetheetiologicalcharacteristicsofnon2bacterialpneumoniainchildreninXipan.MethodsVirusIgMantibodywasdetectedbysolidphaseELISAtechnique,andmycoplasmapneumonia(MP)IgMantibodywasdetectedbyAu2markimmunodottingtechnique.ResultsInatotal
5、of302cases,mycoplasmapneumoniaand/orvirusweredetectedin204,withthepositiveinfectionrateas67.55%(204/302);328caseswerefoundwithpositivestrainsofpathogensincluding120mycoplasma(MP)strains(36.6%)amongwhichwere77coxsackievirus(CV)strains(23.5%),56respiratorysyncytialvirus(RSV)strains(17.1%),39influenza
6、virusstrains(11.9%),25adenovirusstrains(7.6%)and11EBVstrains(3.4%).Thesingleinfectionratewas51.99%(157/302)whilethemixedinfectionratewas15.56%(47/302).Theonsetofnon2bacterialpneumoniainXipancouldbeseeninallseasonsoftheyear.Therewassignificantseasonaldifferenceamongtheincidencescausedbydifferentpath
7、ogens(P<0.05);butnodifferenceindifferentagegroups(P>0.05).Thehighestincidenceagewasbetween7monthsto3years.ConclusionMP,CV,RSVaretheleadingpathogensthatcausenon2bacterialpneumoniainchildreninXipan.ELISAandAu
