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1、#584#中华心血管病杂志2003年8月第31卷第8期ChinJCardiol,August2003,Vol.31No.8#冠心病研究#冠心病患者血浆纤维蛋白原与小而密低密度脂蛋白的关系秦勤耿婕崔让庄毛用敏寇璐赵炳让惠汝太=摘要>目的探讨血浆纤维蛋白原(Fib)水平升高和小而密低密度脂蛋白(sLDL)在冠心病发病中的作用及两者的关系。方法采用Clauss法测定234例经冠状动脉造影证实为冠心病的患者及164例经冠状动脉造影证实无冠状动脉病变的对照者血浆Fib水平,以密度梯度聚丙烯酰胺凝胶电泳法测定sLDL在低密度脂蛋白中
2、所占的比例,同时检测血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平。根据冠状动脉造影的结果将冠心病组分为1支、2支和3支病变组,观察其与Fib及sLDL的关系。结果冠心病组血浆Fib及血脂水平明显高于对照组(HDL-C低于对照组),P<0105,Fib与sLDL水平随冠状动脉病变支数增加而升高(P<0105)。sLDL与冠状动脉病变程度密切相关(r=01452,P<01001),与Fib水平呈正相关(y=4117x+44167)。结论sLDL是冠心病发病的独立
3、危险因素,Fib与sLDL呈正相关,Fib可能间接地对冠心病发病起一定作用。=关键词>纤维蛋白原;脂蛋白类,LDL;冠状动脉疾病;冠状血管造影术Relationshipbetweenfibrinogenandsmalllow-densityloipoproteinparticlesincoronaryheartdiseaseQINQin,GENGJie,CUIRang-zhuang,etal1TianjinChestHospital,Tianjin300051,China=Abstract>ObjectiveToinve
4、stigatetherelationshipbetweensmalllow-densitylipoprotein(sLDL)particlesandfibrinogenincoronaryheartdisease(CHD)1MethodsInacase-controlstudyplasmalipidslevels,smalldenseLDLpercentageoftotalLDLandfibrinogenlevelweremeasuredin234subjectswithangiographicallydocumente
5、dCHDand164subjectswithoutCHD(excludedbycoronarography)1FibrinogenlevelwasdetectedbyClaussandsLDLlevelwasdetectedbyPAGE1Accordingangiography,patientsweredividedintosingle-,double-andtriple-vesselgroups1Weexploredtherelationshipbetweensmall,denseLDLlevelandfibrinog
6、enindifferentgroups1ResultsThelevelsofTC,TG,LDL,smallLDLandfibrinogenweresignificantlyhigherinpatientswithCHDthanthoseincontrols(smallLDL:58170?5125%vs54167?6103%,Fib:3130?0179g/Lvs2182?0172g/L,P<0105)1ThemeanplasmaHDLlevelwaslowerinCHDpatientsthanthatinthecontro
7、lgroup(P<0105)1Asthestenosisvesselsincreased,thesLDLandfibrinogenlevelsalsoincreased(P<0105)1Thefibrinogenlevelsofnostenosis,single-,double-andtriple-vesselgroupwere2196?0174g/L,3132?0190g/L,3140?0190g/L,3152?1100g/L1ThesLDL%was53179?5190,59147?5151,58177?3182,61
8、108?5169inabovegroupsrespectively1WefoundastrongpositivecorrelationbetweensmallLDLpercentageandcoronaryarterystenosisscore(y=015535x+541693,r=01452,P<01001)and
