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《颅内肿瘤危险因素的病例对照研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第48卷第4期山东大学学报(医学版)2010年4月Vol.48No.4JOURNALOFSHANDOOGUNIVERSITY(HEALTHSCIENCES)Apr.2010文章编号:1671-7554(2010)04-0147-04颅内肿瘤危险因素的病例对照研究12324吴敏,李刚,孙金龙,江玉泉,王洁贞(山东大学1.公共卫生学院社会医学与卫生事业管理学研究所,济南250012;2.齐鲁医院神经外科,济南250012;3.第二医院神经外科,济南250033;4.公共卫生学院流行病与卫生统计学研究所,济南250012)摘要:目的
2、探讨颅内肿瘤的危险因素和保护因素。方法采用成组设计病例对照研究方法,对264例原发性颅内肿瘤患者和273例对照进行问卷调查,应用非条件Logistic回归模型推断暴露因素与颅内肿瘤的关系。结果单因素和多因素Logistic回归分析结果表明,源于配偶的被动吸烟、源于同事的被动吸烟、职业性接触汽(柴)油和经常接触农药可增加患颅内肿瘤的危险性,其OR值及95%CI分别为1.777(1.103,2.861)、1.911(1.095,3.334)、4.298(1.008,18.314)和1.728(1.000,3.049)。饮酒和啤酒酒
3、精摄入量<9mL/d可降低患颅内肿瘤的危险性,其OR值及95%CI分别为0.297(0.108,0.821)和0.216(0.046,1.024)。结论颅内肿瘤的危险因素为源于配偶及同事的被动吸烟、职业性接触汽(柴)油和经常接触农药;保护因素为饮酒和啤酒酒精摄入量<9mL/d。关键词:颅内肿瘤;危险因素;病例对照研究中图分类号:R739.41文献标志码:AAcase-controlstudyonriskfactorsofintracranialtumors12324WUMin,LIGang,SUNJin-long,JIANGY
4、u-quan,WANGJie-zhen(1.InstituteofSocialMedicineandHealthAdministration,SchoolofPublicHealth,ShandongUniversity,Jinan250012,China;2.DepartmentofNeurosurgery,QiluHospitalofShandongUniversity,Jinan250012,China;3.DepartmentofNeurosurgery,SecondHospitalofShandongUniversi
5、ty,Jinan250033,China;4.InstituteofEpidemiologyandHealthStatistics,ShandongUniversity,Jinan250012,China)Abstract:ObjectiveToanalyzetherelationshipbetweenexposuresandintracranialtumors.MethodsAhospital-basedcase-controlstudyincluding264casesofintracranialtumorsand273c
6、ontrolswascarriedoutandlogisticregres-sionmodelwasusedtoexplorethepotentialriskfactorsofintracranialtumors.ResultsAccordingtounivariateandmultivariatelogisticregressionmodels,passivesmokingfromspouseandcolleagues,occupationaltouchinggasolineordieselfuel,andusinganin
7、secticideusuallyincreasedtheriskofintracranialtumors,whilealcoholconsumptionandbeeralcoholconsumptionlessthan9mL/ddecreasedtherisk.TheORand95%CIofthesefactorswere1.777(1.103,2.861),1.911(1.095,3.334),4.298(1.008,18.314),1.728(1.000,3.049),0.297(0.108,0.821)and0.216(
8、0.046,1.024).ConclusionRiskfactorsofintracranialtumorsarepassivesmokingfromspouseandcolleague,touchinggasoline,dieselfuelandinsecticides,a
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