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1、培美Illi塞联合顺钳治疗晚期非小细胞肺癌45例近期疗效观察［摘要］目的对培美曲寒联合顺铀治疗晚期非小细胞肺癌(NSCLC)进行临床疗效和毒性评价。方法45例经病理纟fl织学和/或细胞学检杳确诊NSCLC,均为初治患者，其中男性28例，女性17例;年龄31~76岁，中位年龄58岁,鳞癌12例，腺癌30例,腺鳞癌3例,TNM分期:IIIA7例JIIB16例，IV22例，应用培美曲塞联合顺钳治疗，即培美曲塞500mg/m2,顺钳75mg/m2,21d为一周期，至少接受2个周期化疗。按照WHO标准评价临
2、床疗效和毒性。结果45例患者中，无完全缓解(CR)病例，部分缓解(PR)10例，稳定(SD)13例，进展(PD)22例,有效率(CR+PR)22.22%,临床获益率(CR+PR+SD)51.11%,主要毒性反丿应为骨體抑制，胃肠道反应。结论培美1111塞联合顺钳治疗晚期NSCLC疗效可靠，毒性反应小，与国内外文献报道的缓解率及有效率类似。［关键词］培美曲塞;顺钳；晚期非小细胞肺癌；化疗［中图分类号］R734.2［文献标识码］A［文章编号］1673-9701(2009)36-54-03Pemetre
3、xedCombinedwithOxaliplatininTreatmentofAdvaneedNon-smanCellLungConcer:AClinicalObservetionof45CasesBIShutingDepartmentofRespiratory,NanjingMunicipalChestHospital,Nanjing210029,China［Abstract］ObjectiveToobservetheclinicalefficacyandadverseeffectsofpeme
4、trexedcombinedwithoxaliplatintotreatadvancednorrsinallcelllungcancer.MethodsForty-fivecasesaged31^76years(amedianageof58years)werenewlydiagnosedasadvaneednon-smallcelllungcancerbyhistopathologicaland/orcytology,28casesweremaleand17female,andin45cases,
5、12casesweresquamouscellcarcinoma,30wereadenocarcinomaand3wereadenosquamouscarcinoma.TNMstagingshowed7casesofTTIA,16casesofITTBancl22casesofIV・Pemetrexed500mg/m2andcisplatin75mg/m2wereusedforatleast2cyclesofchemotherapywith21claysasacycle.BasedonWHOcri
6、teria,theclinicalefficacyandtoxicitywereevaluated・ResultsIn45patients,therewerenocasesofcompleteremission(CR),10casesofpartialremission(PR)13casesofstablility(SD)and22casesofprogress(PD).Theeffectiverate(CR+PR)was22.22%andtheclinicalbenefitrate(CR+PR+
7、SD)was51.11%,andthemainsideeffectsweremyelosuppressionandgastrointestinaltractreaction.ConelusionThecombinationofpemetrexedandoxaliplatininthetreatmentofadvancednon-smallceillungcancerhasreliableefficacyandfewersideeffects,showingsimilarremissionratea
8、ndeffectiveratereportedinthe1iteratureathomeandabroad.［Keywords］Pemetrexed;Cisplatin;Advaneednon-smallcelllungcancer;Chemotherapy肺癌的发病率和死亡率在过去的一个世纪快速上升，至20世纪末己经成为世界范囤内最重要的人群死因乙一。肺癌是我国第三大恶性肿瘤，发病率也口益上升，忖前已居城市屮常见恶性肿瘤的首位。到2010年我国肺癌患者将达到60力•。肺癌的新发病
