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1、非小细胞肺癌患者血清血管内皮生长因子受体2及内皮抑素及临床特征相关性探究［摘要］目的：探究非小细胞肺癌患者外周血血管内皮生长因子受体2(vascularendothelialgrowthfactorreceptor2,VEGFR-2)和内皮抑素(endostatin,ES)与临床特征的相关性及其意义。方法：选取2009年在上海市第六人民医院心胸外科接受手术治疗的38例非小细胞肺癌(non-smallcelllungcancer,NSCLC)患者，用ELISA法检测其术前血清VEGFR-2.ES水平，分析二者相关性，并分析它们与年龄、性
2、别、病理类型、肿瘤最大直径、肿瘤内血管密度(microvesseldensity,MVD)、临床分期相关性及意义。结果：患者血清ES水平为(20.29土6.10)ug/L,VEGFR-2水平为(7.42±4.28)ug/L,ES表达水平与VEGFR-2表达水平无明显相关性(P>0.05),ES与肺癌病灶内MVD呈直线负相关关系(r=-0.867,r2=0.752),直线回归方程为Y=32.002-0.499X(ug/L)(P<0.001)；ES、VEGFR-2表达水平与其他临床特征无明显相关性(P>0.05)。结论：胸外科NSCLC患
3、者外周血ES水平可能影响肺癌病灶内肿瘤内血管密度，从而影响肿瘤的生长，VEGFR-2.ES可能无法单独作为接受手术治疗NSCLC患者分期及预后判断的有效指标。［关键词］非小细胞肺癌；内皮生长因子受体2；内皮抑［中图分类号］R734.2［文献标识码］A［文章编号］1673-7210(2011)11(c)-024-03ResearchofthecorrelationsbetweenserumlevelsofVEGFR-2,endostatinandclinicalcharactersinpatientswithnon-smallcelll
4、ungcancerYANGYil,2,ZHAOTiancheng2,GAOZongli2,WANGXiuzhenl1.DepartmentofPathology,MedicalCollegeofSoochowUniversity,CollegeofBasicMedicalandBiologicalSciences,JiangsuProvince,Soochow215006,China；2.DepartmentofcardiothoracicSurgery,the6thPeople"sHospitalAffideatedtoShangh
5、aiJiaoTongUniversity,Shanghai200233,China[Abstract]Objective：Tostudytherelationshipbetweenclinicalsignificanceandtheserumlevelsofvascularendothelialgrowthfactorreceptor2(VEGFR-2),endostatin(ES)inpatientswithnon-smallcelllungcancer(NSCLC)・Methods：TheserumVEGFR-2,ESlevels
6、weredetectedbyELISAmethodin38patientswithNSCLCinShanghai6thPeople，sHospitalcardiothoracicsurgerydepartmentin2009.ThecorrelationswereanalyzedamongVEGFR-2,ESandtheclinicalcharacters,age,sex,pathology,diameteroftumor,clinicalstage,microvesseldensity(MVD)oftumor.Results：The
7、serumlevelofES[(20.29±6.10)yg/L]wasuncorrelatedwiththatofVEGFR-2[(7.42土4.28)ug/L](P>0.05)；theserumlevelofESwascorrelatedwithMVDoftumor(r=一0・867,r2-0.752),thelinearregressionequationwas[Y=32.002一0.499X(pg/L)](P<0.001)；ESandVEGFR2wereuncorrelatedwiththeotherclinicalcharac
8、ters・Conclusion：TheserumlevelofESmaychangetheMVDoftumor,ES,VEGFR-2andtheclinicalcharactersareuncorrelatedinNSC
