To Fold or To Fibrillate Serendipity in Stability Studies折叠还是Fibrillate？稳定性研究中地偶然性.pdf

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1、ToFoldorToFibrillate?SerendipityinStabilityStudiesSzczepankiewicz,OlgaPublished:2011-01-01LinktopublicationCitationforpublishedversion(APA):Szczepankiewicz,O.(2011).ToFoldorToFibrillate?SerendipityinStabilityStudiesGeneralrightsCopyrightandmoralrightsforthepublicationsmadea

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accesstotheworkimmediatelyandinvestigateyourclaim.Downloaddate:08.Aug.2018PrefaceProteinsarefascinatingmolecules,complicatedtounderstandbytheirownandevenmoresowhiletakingpartinvariousreactionsandcrowdedenvironmen

5、ts.Inordertoelucidatesomeofthiscomplexity,propertiesofaproteininasimplesystemareusuallyinvestigated.Theaminoacidsinaproteininteractnon-covalentlywitheachotherandthesurrounding.Eachkindofinteractionbyitselfiswellunderstoodbuttheirinterplayinaproteinsystemisnoteasytopredict.U

6、sually,aproteinfoldsintoitsnativeandfunctionalstructurewithoptimizedinteractions.However,undercertainconditions,aproteinmayformdifferentkindsofaggregates.Someofthemarejustrandomprecipitatesandothers,suchasamyloidfibrils,haveawell-orderedstructure.Manydiseasesareassociatedwi

7、thamyloidstructuresofproteins.Inthisthesis,Ihavebeenlookingatdifferentproteinsandhowthesewereaffectedbyvariousmutations.Insomecases,theproteinstabilityincreasedduetoimprovedinteractionswhileinothercasesthemutationsledtolessstableandaggregatingproteins.Itisallaboutthebalance

8、andinterplayofthenon-covalentinteractionsinandaroundaprotein.Thetitleofthethesis,“