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《The effect of immune-complex formation on the distribution of a novel antibody tothe ovarian tumor antigen CA125 免疫复合物形成对新型抗体分布地影响 卵巢肿瘤抗原CA125.pdf》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、DMDFastForward.PublishedonSeptember7,2010asDOI:10.1124/dmd.110.034330DMDFastForward.PublishedonSeptember7,2010asdoi:10.1124/dmd.110.034330Thisarticlehasnotbeencopyeditedandformatted.Thefinalversionmaydifferfromthisversion.DMD#34330Theeffectofimmune-complexformationonthedistr
2、ibutionofanovelantibodytotheovariantumorantigenCA125CinthiaV.Pastuskovas,WilliamMallet,SuzannaClark,MargaretKenrick,MohammedMajidy,MichelleSchweiger,MarjieVanHoy,SiaoPingTsai,GregoryBennett,Ben-QuanShen,SarajaneRoss,PaulFielder,LeslieKhawli,andJayTibbitts.DownloadedfromPharm
3、acokineticandPharmacodynamicSciences(C.V.P.,M.K.,B.Q.S.,P.F.,L.K.,dmd.aspetjournals.orgJ.T.),CancerTargets(W.M.),TranslationalOncology(S.C.,S.R.),PathologyLabs(M.M.,M.V.H.),SafetyAssessment(M.S.),AssayandAutomationTechnology(S.P.T.,G.B.).Genentech,Inc.,SouthSanFrancisco,Cali
4、fornia.atASPETJournalsonSeptember2,20181Copyright2010bytheAmericanSocietyforPharmacologyandExperimentalTherapeutics.DMDFastForward.PublishedonSeptember7,2010asDOI:10.1124/dmd.110.034330Thisarticlehasnotbeencopyeditedandformatted.Thefinalversionmaydifferfromthisversion.DMD#34
5、330a)RunningTitle:Preclinicaldistributionofananti-MUC16antibodyb)CorrespondingAuthor:JayTibbitts,640E.GrandAve.,SouthSanFrancisco,CA94080.Phone:650-467-3194;FAX:650-742-5234.E-mail:tibbitts@gene.comc)Numberoftextpages:27Numberoftables:0Numberoffigures:6DownloadedfromNumberof
6、references:37NumberofwordsintheAbstract:243dmd.aspetjournals.orgNumberofwordsintheIntroduction:704NumberofwordsintheDiscussion:814d)Abbreviations:ADC,antibody-drugconjugate;AUC,areaundertheconcentration-timeatASPETJournalsonSeptember2,2018curve;ELISA,enzyme-linkedimmunosorbe
7、ntassay;IC,immune-complex;luc,luciferase-expressing;PBS,phosphate-bufferedsaline;PIs,phosphor-imagingplates;QWBA,quantitativewhole-bodyautoradiography;SEC-HPLC,sizeexclusionhigh-performanceliquidchromatography;SCID,severecombinedimmunodeficiency;TCA,trichloroaceticacid;µCi:m
8、icrocurie.2DMDFastForward.PublishedonSeptember7,2010asDOI:10.1124/dmd.110.0
