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时间:2020-03-25
《ICGR15联合PT及标准残肝体积预测肝癌患者术后肝功能恢.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、342肝胆外科杂志2013年10月第21卷第5期JournalofHepatobiliarySurgery,Vol,21,No.5,Oct.2013ICGR15联合PT及标准残肝体积预测肝癌患者术后肝功能恢复1213李江发,胡虞乾,何松青,陈孝平【摘要】目的探讨术前吲哚氰绿15分钟滞留率(indocyaninegreenretentionrateat15min,ICGR15)联合术前凝血酶原时间(prothrombintime,PT)及标准残肝体积(standardremnantlivervolume,SRLV)对预测肝癌患者术后肝功能代偿
2、的作用。方法对64例因大肝癌行肝切除术的患者进行研究,根据术后患者肝功能代偿情况分组,对术前生化检查及一般情况进行差异性分析。结果轻度肝功能代偿不全组(50例)、中重度肝功能代偿不全组(14例)之间ICGR15、PT、SRLV有统计学意义(P<0.05);Logistic回归分析得到回归方程为:PLFPI=0.186×ICGR15+0.849×PT-0.007×SRLV-9.617。经过ROC分析PLFPI预测术后肝功能重度代偿不全的临界值为-0.33,其灵敏度为100%,特异度为87.10%。结论术前ICGR15联合术前PT及标准残肝体积
3、能够较好地预测肝癌患者术后肝功能代偿情况;以PLFPI<-33作为预防大肝癌肝切除术后重度肝功能代偿不全的术后肝功能综合预测指数界限是可行的。【关键词】肝功能储备;标准残肝体积;ICGR15;PT【中图分类号】R735.7【文献标识码】A【文章编号】1006-4761(2013)05-0342-04ICGclearancetestcombinedwithprothrombintimeandstandardremnantlivervolumepredicttherecoveryofpostoperative121liverfunctionin
4、patientswithhepatocellularcarcinoma(LIJiang-fa,HUYu-qian,HESong-qing,etal.1、DepartmentofHepatobiliaryandPancreaticSurgery,AffiliatedHospitaltoGuilinMedicalCollege,Guilin541001,China;2、DepartmentofHepatobili-aryandPancreaticSurgery,AffiliatedNanxishanHospitaltoGuilinMedical
5、College,Guilin541002,China)【Abstract】ObjectiveToexplorethepreoperativeICGclearancetestcombinedwithpreoperativeprothrombintimeandstand-ardremnantlivervolumeinpredictingtherecoveryofpostoperativeliverfunctioninpatientswithhepatocellularcarcinoma.MethodsSixty-fourpatientswith
6、largehepatocellularcarcinomaunderwenthepaticresectionfrom2010Januaryto2013FebruaryatAffiliatedHospitalofGuilinMedicalCollegewereincludedinourstudy.Thepatientsweredividedintotwogroupsbasedonthelevelofliverfunctioncompensationafterhepatectomy.Thedifferencesofpreoperativeexam
7、inationbiochemicalandgeneralsituationwereanalyzed;LogisticregressionanalysisandROCanalysisontherelationshipbetweenpreoperativeICGR15,prothrombintime,standardresiduallivervolumeandpostoperativemoderatetosevereliverfunctiondecompensationgroupwasanalyzed.ResultsBetweenmildhep
8、aticdecompensationgroupandmoderatetoseverehepaticdecompensationgroup,ICGR15,prothrombinti
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