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《低钙透析液对钙磷及甲状旁腺功能的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、成都医学院学报2O14年第9卷第5期JournalofChengduMedicalCollege,2014,Vo1.9,No.5网络出版地址:http://www.cnki.net/kcms/detail/51.1705.R.20141016.1101.002.htmldoi:10.3969/j.issn.1674—2257.2014.05.014临床报道·低钙透析液对钙磷及甲状旁腺功能的影响-R-牟爱华,赵建明,庞玉洪,张小翠重庆市涪陵中心医院肾内科(重庆408000)【摘要】目的探讨低钙透析液对维持性血液透析患者血清钙、磷、钙磷乘积及全段甲状旁腺激素(iPTH)
2、的影响及临床应用适应症。方法4O例维持性血液透析患者随机分为观察组和对照组各2O例。在行血液透析治疗过程中,观察组给予低钙透析液(钙离子浓度为1.25mmol/L),对照组给予常规钙透液(钙离子浓度为1.5mmol/L),疗程6个月,观察血钙、血磷、钙磷乘积、iPTH、超敏C反应蛋白(hsCRP)等指标及不良反应。结果与对照组同期比较,观察组血清钙、钙磷乘积降低,iPTH升高,差异有统计学意义(P<0.05);观察组hsCRP为(2.96±0.61)mg/L;对照组hsCRP为(6.564-0.91)mg/L,两组比较差异有统计学意义(P3、能降低血清高钙负荷,改善被过度抑制的甲状旁腺功能,具有更好的达标率,适用于iPTH正常或偏低而透析前无严重低钙血症的血液透析患者。【关键词】低钙透析液;血液透析;钙磷代谢;甲状旁腺激素;微炎症;达标率【中图分类号】R692.5【文献标志码】BInfluenceoftheLowCalciumDialysateonCalciumPhosphateandParathyroidHormoneHome~tasisMOUAi—hua,ZHAOJian—ming,PANGYu—hong,ZHANGXiao—cui.DepartmentofUrology,FulingCentrer4、Hospital0/’ChongqingCity,Chongqing408000,China[Abstract]ObjectiveToinvestigatetheeffectsofdialysatewithlowcalciumoncalciumserum,phosphatemetabolismandimmunoreactiveparathyroidhormone(iPTH)inthehemodialysis(HD)patients.MethodsFortyHDpatientswererandomlyandevenlydividedintotheDCa一1.25gro5、up(1.25mmol/L)andtheDCa-1.50(1.50mmol/L)group.Allpatientsweretreatedforsixmonths.Theindexvalueoftheserumconcentrationsofcalcium,phosphorous,iPTHandhsCRPweremeasured,SOwastheuntowardreaction.ResultsComparingwiththecontrolgroup,theserumconcentrationsofcalciumandcalcium×phosphateweredecre6、ased(P<0.05),theserumconcentrationsofiPTHincreasedintheDCa一1.25group(P<0.05);andthehsCRPconcentrationintheDCa:1.25groupwas(2.96±0.61)mg/Lcontrastingto(6.56±0.91)mg/LinDCa-1.50group(P<0.05).ConclusionThetreatmentwith1.25mmol/Lcalciumdialysatecandecreaseserumcalciumandcalcium×phosphatean7、dstimulatethesecretionofparathyroidhormonewhichissuitableforHDpatientswithrelativelydeficientiPTHandrain-hypocalcemiabeforetheoperation.[Keywords]Lowcalciumdialysate;Hemodialysis;Calcium;Phosphorus;Parathyroidhormone;Inflammation终末期肾脏病患者常出现血清钙、磷、甲状旁腺移性钙化加重。流行病学调查【2发现,血液透析功能异常等代谢紊乱,其可
3、能降低血清高钙负荷,改善被过度抑制的甲状旁腺功能,具有更好的达标率,适用于iPTH正常或偏低而透析前无严重低钙血症的血液透析患者。【关键词】低钙透析液;血液透析;钙磷代谢;甲状旁腺激素;微炎症;达标率【中图分类号】R692.5【文献标志码】BInfluenceoftheLowCalciumDialysateonCalciumPhosphateandParathyroidHormoneHome~tasisMOUAi—hua,ZHAOJian—ming,PANGYu—hong,ZHANGXiao—cui.DepartmentofUrology,FulingCentrer
4、Hospital0/’ChongqingCity,Chongqing408000,China[Abstract]ObjectiveToinvestigatetheeffectsofdialysatewithlowcalciumoncalciumserum,phosphatemetabolismandimmunoreactiveparathyroidhormone(iPTH)inthehemodialysis(HD)patients.MethodsFortyHDpatientswererandomlyandevenlydividedintotheDCa一1.25gro
5、up(1.25mmol/L)andtheDCa-1.50(1.50mmol/L)group.Allpatientsweretreatedforsixmonths.Theindexvalueoftheserumconcentrationsofcalcium,phosphorous,iPTHandhsCRPweremeasured,SOwastheuntowardreaction.ResultsComparingwiththecontrolgroup,theserumconcentrationsofcalciumandcalcium×phosphateweredecre
6、ased(P<0.05),theserumconcentrationsofiPTHincreasedintheDCa一1.25group(P<0.05);andthehsCRPconcentrationintheDCa:1.25groupwas(2.96±0.61)mg/Lcontrastingto(6.56±0.91)mg/LinDCa-1.50group(P<0.05).ConclusionThetreatmentwith1.25mmol/Lcalciumdialysatecandecreaseserumcalciumandcalcium×phosphatean
7、dstimulatethesecretionofparathyroidhormonewhichissuitableforHDpatientswithrelativelydeficientiPTHandrain-hypocalcemiabeforetheoperation.[Keywords]Lowcalciumdialysate;Hemodialysis;Calcium;Phosphorus;Parathyroidhormone;Inflammation终末期肾脏病患者常出现血清钙、磷、甲状旁腺移性钙化加重。流行病学调查【2发现,血液透析功能异常等代谢紊乱,其可
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