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1、原发性肝癌介入治疗前后凝血及纤溶功能变化及临床意义AlternationandClinicalSignificaneeofBloodCoagulationandFibrinolyticFunctionBeforeandAftertheInterventionalTherapyofPrimaryHepatocellularCarcinoma王磊1田开荣1孙达春2Wang-Le1Tian-kairong1SHUNDa-chun2珠海振国肿瘤康复医院1(中国519000)ZhuhaiZhenGuoTumorRehabilitationHospital(Chi
2、na519000)珠海市人民医院2(中国519000)People'sHospitalofZhuHai(China519000)中图分类号：R735.7文献标识码：A文章编号:1818-0086(2011)05摘要:目的研究原发性肝癌介入治疗前、后凝血及纤溶功能的变化。方法血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原含量(Fg)、凝血因子VII(FVII)、凝血因子Vlll(FVIII)、因子X(FX)采用光散射比浊法。P■选择素(Ps),血管性血友病因子(vWF),尿激酶型纤溶酶原激活物(uPA)采用EL
3、ISA法测定。uPA抑制物(PAI)采用发色底物法。结果1.与对照组比较，治疗前PT、APTT、TT、Ps、VWF、uPA升高，Fg、FVIkFVIIkFX降低。2.与治疗前比较，治疗后PT、APTT、Ps、VWF、uPA降低，FVIkFVIII升高。3.与对照组比较，治疗后PT、APTT、TT、Ps、vWF、uPA升高，Fg、FVILFVIIkFX降低。结论原发性肝癌患者血凝降低，纤溶亢进，血小板活化，介入治疗后减轻，但未恢复正常。关键词原发性肝癌；介入治疗；凝血；纤溶；血小板活化Abstraet:PurposeTostudythechangerso
4、fbloodcoagulationandfibrinolyticfunctionbeforeandafterinterventionaltherapyofprimaryhepatocellularcarcinomaMethodsToanalyzeProthrombintime(PT),activatedpartialthromboplastintime(APTT),thrombintime(TT),fibrinoger(Fg),coagulatefactorVII(FVII),factorVIII(FVIII),factorX(FX)withtheli
5、ghtscatteringturbidimetry,andP・Selectin(Ps),VouWillebrandfactor(vWF),urokinaseprofibrinolyticactivatingfactor(uPA)wereexaminedbyELISA,uPA'sinhibitor(PAI)withthechromogenicSubstances.Results1.PT,APTT,TT,Ps,vWFanduPAingroupbeforetherapywerehigerthanthoseingroupcontrolwhileFg,FVII,
6、FVIIIandFXingroupbeforetherapywerelessthanthoseingroupcontrol.2.PT,APTT,Ps,vWFanduPAingroupaftertherapywerelessthanthoseingroupbeforethatwhileFVIIandFVIIIingroupaftertherapywerehigerthanthoseingroupbeforethat.3.PT,APTT,Ps,vWFanduPAingroupaftertherapywereIhigerthanthoseingroupcon
7、trolwhileFg,FVII,FVIIIandFXingroupaftertherapylessthanthoseincontrol.ConclusionThebloodcoagulationofprimaryhepatocellularcarcinomaweredecreased,thefibrinolysiswasincreased,plateletwasactivated,andabatedafterinterventionaltherapy,butnotresumenormal.Keywords:primaryhepatocellularc
8、arcinoma;interventionaltherapy;bloodcoagulation
