冠状病毒Coronavirusl论文-2002 The Use of Bovine Serum Protein as an Oral Support Therapy Following Coronavirus Challenge in Calves.pdf

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1、J.DairySci.85:1249–1254AmericanDairyScienceAssociation,2002.TheUseofBovineSerumProteinasanOralSupportTherapy1FollowingCoronavirusChallengeinCalvesJ.D.Arthington,*C.A.Jaynes,†H.D.Tyler,‡S.Kapil,§andJ.D.Quigley,III†*RangeCattleResearchandEducationCenterUniversityofFl

2、orida—IFAS,Ona33865†AmericanProteinCorporation,Inc.,Ames,IA50010‡DepartmentofAnimalSciencesIowaStateUniversity,Ames50010§CollegeofVeterinaryMedicineKansasStateUniversity,Manhattan66506ABSTRACT(Keywords:bovineserum,coronavirus,calf)Theobjectiveofthisexperimentwastoin

3、vestigateAbbreviationkey:BCV=bovinecoronavirus,PCVthetherapeuticefficacyofasupplementalbovineserum=packedcellvolume.proteinblendfedtocalveschallengedwithvirulentcoronavirus.TwelveHolsteinbullcalves(approxi-INTRODUCTIONmately3wkofage)wereallocatedbyinitialbodyweightOv

4、er50%ofdairycalfmortalityonUSdairyfarmsistoControl(n=5)andtreated(n=7)groups.Ond0,7relatedtodiarrhea(NAHMS,1994).Acommonentericallcalveswereorallychallengedwith1×10plaque-pathogeninfectingyoungdairycalvesisbovinecoro-formingunitsofvirulentcoronavirusisolate.Infectio

5、nnavirus(BCV).Bovinecoronavirusaffectsbothdairywasallowedtoprogressfor24hbeforetreatmentwasandbeefandismostcommonincalves1to2wkofagestarted.Ond1,treatedcalvesbeganreceiving160g(Clark,1993).Inadultcattle,BCVhasbeenlinkedtoofdrybovineserumpowder(16gIgG)mixedintomilkwi

6、nterdysentery,adiarrhealconditionaffectingreplacerpowder(67g)atbothana.m.andp.m.feeding.housedcattle(Clark,1993).ThemodeofinfectionisControlcalvesreceivedonlymilkreplacerpowder(227oftenviatheoralroute,andbothentericandrespira-g)atbothfeedings.Responsetocoronavirusch

7、allengetoryBCVinfectionhasbeenshown(Reynolds,1983).anddietarytreatmentwasmonitoredpriortoa.m.andCalfmorbidityratesfromnaturallyoccurringBCVin-p.m.feedingbythecollectionofmultipleclinicalmea-fectionmaybeashighas15to25%(Langpapetal.,sures.Fecalconsistencywasdecreasedb

8、ycoronavirus1979).Strictsanitationandisolationofneonatalcalveschallengebutwasnotaffectedbydietarytreatment.canbeimplementedtohelppreventin