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1、879MonoclonalAntibodytotheReceptorforMurineCoronavirusMHV-A59InhibitsViralReplicationInVivoAbigailL.Smith,ChristineB.Cardellichio,SectionofComparativeMedicineandDepartmentofEpidemiologyandDeborahF.Winograd,MarkS.deSouza,PublicHealth,YaleUniversity,NewHaven,Connecticut;Departme
2、ntpfStephenW.Barthold,andKathrynV.HolmesPathology,UniformedServicesUniversityoftheHealthSciences,Bethesda,MarylandBecausemanystrainsofmousehepatitisvirus(MHV)infectlaboratorymice,noeffectivevac•cinehasyetbeendeveloped.AnalternativeapproachtocontrolMHVdiseaseistheuseofahostcell
3、receptor-targetedligand.Toaddressthepotentialusefulnessofthisapproach,amono•clonalantibodydirectedagainstthehostcellreceptorforthecoronavirusMHV-A59wasad•ministeredtoinfantmicethatwerethenchallengedoronasallywith1()4intracerebralinfantmousemedianlethaldosesofMH'-A59.Antibodyt
4、reatmentofvirus-challengedmiceresultedinlowerproportionsofmicewithMHV-A59intargetorgansandmarkedlyreducedviraltitersintheseorganscomparedwithmock-treatedinfectedmice.Someantibody-treatedinfectedmicesurvivedfor7daysafterviralchallenge,whereasnomock-treated,infectedmicesurvivedb
5、e•yondday3afterviralinoculation.Theseresultssupportareceptor-targetedapproachtointer•ventionincoronavirusdisease.DownloadedfromViralreceptorsplayimportantrolesindeterminingthespe•[8,9].Comparablemembranepreparationsfromgeneticallyciesspecificity,tissuetropism,andpathogenesisof
6、animalresistantSJLmicedonotbindMHV-A59[8,9].Thesestudiesjid.oxfordjournals.orgviralinfectionsinvivo[1].ReceptorsforvirusesinmanysuggestthatgeneticallybasedsusceptibilitytoMHV-A59maydifferentgroupshavebeenrecentlyidentified,leadingtoeffortsbedetermined,atleastinpart,byexpressio
7、nofthevirus•toinhibitviralinfectioninvitroandinvivobyblockingvirus•bindingmoietyontheplasmamembranesofnormaltargetreceptorinteractions[2-5].Areceptor-targetedapproachap•tissuesforMHV.atUniversityofExeteronAugust16,2015pearsmostlikelytebeeffectiveinviraldiseasesinwhichApanelofm
8、onoc1onalantibodies(MAbs)reactivewiththethevirusentersthebody
