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1、JournalofNeuroimmunology,12(1986)13l-142131ElsevierJNI00384MurineCoronavirus-InducedEncephalomyelitidesinRats:AnalysisofImmunoglobulinsandVirus-SpecificAntibodiesinSerumandCerebrospinalFluidR.DiSrries*,R.Watanabe,H.WegeandV.terMeulenInstitutfftrVirologieundImmunbiologie.Universiti~tW'ftrzburg,Versba
2、cherStr.7.D-8700W'ftrzburg(F.R.G.)(Received1October,1985)(Revised,received6January,1986)(Accepted6January,1986)Summa~Thehumoralintrathecalimmuneresponseincoronavirus-induceddemyelinatingencephalomyelitisinratsassociatedwithanautoimmunereactiontobrainantigen,wasanalysed.TheCSFoftheseanimalsrevealedim
3、munereactionswhichweredirectedagainstcoronavirusandother,unknown,antigens.Ingeneral,nodirectcorrelationbetweenthedisease,thestateoftheblood-brainbarrier(BBB),intrathe-calsynthesisofIgandthepresenceofvirus-specificantibodieswasdetectable,suggestingthatthehumoral,incontrasttothecellular,immuneresponse
4、doesnotplayasignificantpathogeneticroleinthisCNSdisease.Keywords:CoronavirusJHM-Intrathecalantibodyresponse-Subacutede-myelinatingencephalitisIntroductionMurinecoronavirusesarehighlyneurotropicformiceandratsandcausecentralnervoussystem(CNS)disordersrangingfromacutetosubacuteencephalomyelitis*Towhomr
5、eprintrequestsshouldbeaddressed.0165-5728/86/$03.50~'1986ElsevierSciencePublishersB.V.(BiomedicalDivision)132(StohlmanandWeiner1981:Knobleretal.1982a,b:Wegeetal.1982:kavietal.1984:Woyciechowskaetal.1984).Ofparticularinterest,arethesubacuteinfectionsbythevirusstrainJHMwhichcanbeassociatedwithmarkedin
6、flammatorydemyelinatinglesions,especiallyinrats(Nagashimaetal.1978,1979:Sorensenetal.1980).Thissubacutedemyelinatingencephalomyelitis(SDE)developsweekstomonthsafterviralinoculationandischaracterizedneuropathologicallybyprimarydemyelinationinthebrainandthespinalcordandbyinflammatorychangesconsistingm
7、ainlyofinfiltrationbymacrophagesandlymphocyteswithperivascularcuffinginthevicinityofplaques.Duringtheclinicaldisease,theviruscanbeisolatedfromthebrainandthespinalcordtissueandviralantigensaredetectabl
