心力衰竭患者血清可溶性ST2受体的变化及意义.doc

《心力衰竭患者血清可溶性ST2受体的变化及意义.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、心力衰竭患者血清可溶性ST2受体的变化及意义［摘要］目的测定心力衰竭患者不同时间点的血清可溶性ST2受体浓度，分析其在心力衰竭早期诊断及病情评估方面的意义。方法选择心力衰竭患者60例作为实验组，对照组60例。评价其心功能情况及临床变化。ELISA法测定患者入院时、第3天血清可溶性ST2受体水平、N-末端脑利钠肽前体及测定入院时的左室射血分数。结果实验组血清可溶性ST2受体（sST2）水平显著高于对照组，左心室射血分数显著低于对照组,差异均有统计学意义（1X0.05）。血清可溶性ST2受体（sST2

2、）水平与N-末端脑利钠肽前体呈正相关（PC0.01）,与左心室射血分数（LVEF）呈负相关（P〈0・01）。结论血清可溶性ST2受体（sST2）浓度可以作为判断患者有无心力衰竭的实用指标，并且对于心力衰竭严重程度的判断有重要的指导意义，指导临床诊断及治疗。由于sST2浓度与LVEF值呈负相关，有望通过sST2浓度来预测患者的LVEF值。［关键词］心力衰竭；血清可溶性ST2受体；诊断［中图分类号］R541.6［文献标识码］B［文章编号］1673-9701（2014）32-0016-03Thechan

3、gesandsignificanceofsolubleST2receptorinheartfailurepatientsGUOYongjunGUANYongdongCHENJunKONGYuanyuanDENGSuzhenQIUMinCHENJiewenDepartmentofEmergency,thePeople'sHospitalofQingyuanCityinGuangdongProvince,Qingyuan511500,China[Abstract]ObjectiveTodetermin

4、econcentrationsofserumsolubleST2receptors(sST2)ofpatientswithheartfailureatdifferenttimepointsandanalyzeitssignificanceinearlydiagnosisandConditionassessmentofheartfailure.MethodsSixtypatientswithheartfailureweretakenastheexperimentgroupand60peoplewit

5、houtheartfailureweretakenasthecontrolgroup.Theircardiacfunctionandclinicalchangeswereevaluated.TheELISAmethodwasusedtomeasuretheserumsolubleST2receptorsconcentrationonadmissionandonthe3thdayandmeasureleftventricularejectionfraction(LVEF)andN-terminalp

6、ro-brainnatriureticpeptideprecursors(NT-proBNP).ResultsTheexperment.groupwassignificantlyhigherthanthecontrolgroupintheserumsST2levelandwassignificantlylowerintheLVEF,withstatisticallysignificantdifference(P<0.05)・ThesST2concentrationandNT-proBNPvalue

7、waspositivelycorrelated(P<0.01),andwasnegativecorrelationwiththeleftventricularejectionfraction(P<0.01)•ConelusionSerumsST2concentrationcanbeusedasajudgewhetherthereareheartfailurepatientswithsensitiveindex,andcanbeusedtojudgetheseverityofheartfailure

8、,becausethesST2concentrationandLVEFvalueisnegativelycorrelated,isexpectedtothroughthesST2concentrationtopredictthepatientsLVEFvalue.[Keywords]Heartfailure；SerumsolubleST2receptor(sST2)；Diagnosis心肌肥厚及心肌纤维化是许多心脏疾病，包括心肌樓死、高血压和瓣膜病的共同病理生理过程，传统观念认为这