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1、培美Illi塞、多西他赛联合顺鉗一线治疗晚期肺腺癌的疗效观察［摘要］目的：比较培美曲塞(PEM)联合顺钳(DDP)与多西他赛(DOC)联合DDP治疗晚期肺腺癌的临床疗效及毒性反应。方法：将44例晚期肺腺癌(IIIB〜IV期)患者随机分为培美曲塞加顺钳组(PC组)和多西他赛加顺钳组(DC组),每组22例。PC组,PEM500mg/m2+生理盐水100ml,静滴10〜30min,第1天；DC组,D0C75mg/m2+生理盐水250ml静滴1h,第1天。两纽DDP均为25mg/m2,第1〜3天给药；每21天重
2、复。治疗2个周期后评价疗效，治疗期间观察不良反应。结果：PC组总有效率为45.5%,屮位无进展时间5.5个月；DC组总有效率为40.9%,中位无进展时间4.8个月。两纟R比较差异均无统计学意义(均P>0.05)。PC组骨箭抑制、胃肠道反应、肝肾功能损害等毒性反应显著低于DC组(均P<0.05)。结论：培美曲塞联合顺钳治疗晚期非小细胞肺癌的疗效与多西他赛加顺钳的疗效相当，但毒性反应明显减少，可作为晩期肺腺癌患考的一线治疗用药。［关键词］肺腺癌；一线化疗；培美曲塞；多西他赛；顺钳［中图分类号］R734.2［
3、文献标识码］A［文章编号］1673-7210(2011)11(c)-078-03ObservationofcurativeeffectonPemetrexedorDocetaxelplusCisplatininthefirst-linetreatmentofpatientswithlungadenocarcinomaCHENShouhua,YAOWeidong,GUHongbingDcpartmentofMedicalOncology,NantongTumorHospital,JiangsuProvin
4、ce,Nantong226361,China［Abstract］Objective:ToobservetheefficacyandtoxicityofPemetrexedorDocetaxelplusCisplatininthefirst-linetherapyofpatientswithlungadenocarcinoma.Methods:44patientswithlatestagelungadenocarcinoma(thestageofIIIB-IV)wereenrolledintothisst
5、udy.ThesepatientsweredividedintoPCgroup(PemetrexedplusCisplatin)andDCgroup(DocetaxelplusCisplatin),with22casesineachgroup,groupPC:Pemetrexed500mg/m2plusnormalsaline100ml,10-30minivgtt,inthefirstday;DCgroup:Docetaxel75mg/m2plusnormalsaline250ml,1hivgtt,in
6、thefirstday.BothgroupsweregivenCisplatin25mg/m2ivgtt,dl-3.Thetreatmentwouldberepeatedevery21days・Theefficacyandtoxicityofpatientsafterreceivingtwocycleswillbeevaluated.ResuIts:Theoverallresponseratewas45.5%inPCgroupand40.9%inDCgroup.Theaveragetimeforprog
7、ressivediseasewas5.5monthsinPCgroupond4.8monthsinDCgroup.Nosignificantstatisticaldifferencesintheoverallresponseratesandtheaveragetimeforprogressivewerefoundbetweenthetwogroups(P>0.05).Thesideeffectsofmyelosuppression,gastrointestinaldisorders,toxityof1i
8、verandkidneyandhematologictoxicitiesinPCgroupwerelessandslighterthanDCgroup(P<0.05).Conclusion:PemetrexedplusCisplatinhasthesameactivityasDocetaxelplusCisplatininthetreatmentofpatientswithlungadenocarcinoma,butthetoxicitie
