[精品]急性白血病患者HGF及VEGF血清水平检测的临床相关研究.doc

《[精品]急性白血病患者HGF及VEGF血清水平检测的临床相关研究.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、急性白血病患者HGF及VEGF血清水平检测的临床相关研究急性白血病患者HGF及VEGF血清水平检测的临床相关研究［摘要］目的:检测急性白血病(acuteleukemia,AL)患者治疗前后外周血血清肝细胞生长因子(hepatocytegrowthfactor,HGF)和血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)的水平，探讨血清HGF和VEGF与急性白血病的发生、发展及预后等方面的关系。方法：应用双抗体夹心酶联免疫吸附试验(enzyme-linkedimmunosorbentassay,ELSTA)动态检

2、测并分析患者不同时期血清HGF和VEGF水平检测。所有数据均采用SPSS13.0统计软件分析。结果：(l).ANLL组血清HGF水平明显高于正常对照组，差异有统计学意义(P<0.01)；(2).ALL组血清HGF水平明显高于正常人对照组水平，差异有统计学意义(P<0.01)；(3).ANLL患者CR组治疗前后血清HGF水平差异有统计学意义(P〈0・01),NR组治疗前后血清HGF水平差异无统计学意义(P>0.05)o结论：(1).AL患者血清HGF及VEGF水平均较正常对照组升高。(2).血清HGF及VEGF水平可作为监测急性白血病的疗效指标。(3)•

3、血清VEGF水平可作为急性白血病的预后判断指标，血清HGF水平对白血病的预后判断有一定意义。［关键词］白血病；肝细胞生长因子；血管内皮细胞生长因子；酶联免疫吸附试验［ABSTRACT］ObjectiveTodeterminetheserumlevelsofhepatocytegrowthfactor(HGF)andvascularendothelialgrowthfactor(VEGF)inpatientswithALandtostudytherelationshipbetweenthelevelsofHGFandVEGFandtheoccurrenc

4、e,progress!onandprognosisofAl八MethodsWeremeasuredbyenzyme-1inkedimmunosorbentassay(EIJSA),andsomeotherrelateditemsweredeterminedaswel1.TocomparethevariationofHGFandVEGF1evelsofALpatientspretreatedandpost-treatedandtoobservethecorrelation,AlldataswereanalyzedbySPSS13.0.Results(1)

5、.SerumHGFlevelsofANLLwerehigherobviouslythanthoseofnormalsubjectsandthedifferencewassignificant(P<0.01)；(2).SerumHGFlevelsofALLwerehigherobviouslythanthoseofnormalsubjectsandthediffereneewassignificant(P<0.01)；(3)・SerumHGFlevelsofANLLCRgroupwere(1140.31±266.23)pg/ml,(478.50土183.

6、75)pg/mlrespectivelybeforeandaftertreatment,andthedifferencebetweenthemwassignificant(P〈0・01)；SerumHGFlevelsofANLLNRgroupwere(1432.51±235.30)pg/ml,(1386・63±197.95)pg/mlrespectivelybeforeandaftertreatment,andthedifferencebetweenthemwasnotsignificant(P>0・05).Conclusion(1).SerumHGF

7、andVEGFlevelsinpatientswithALLandANLLarehigherthanthoseofnormalsubjects・(2).SerumHGFandVEGFareusefulitemsfordetectingtheeffectoftreatmentinALLandANLL・(3).SerumVEGFisavaluableitemforevaluationprognosisinbothALLandANLL,andserumHGFforevaluationprognosisisalsoavaluableiteminALLandAN

8、LL.(4).PositivecorrelationisshownbetweenserumHG