资源描述：
《DARPA's Big Mechanism programDARPA的大机制安排计划.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。
1、PhysicalBiologyPAPER•OPENACCESSRelatedcontent-Modelingfor(physical)biologists:anDARPA'sBigMechanismprogramintroductiontotherule-basedapproachLilyAChylek,LeonardAHarris,JamesRFaederetal.Tocitethisarticle:PaulRCohen2015Phys.Biol.12045008-Fromphysicstopharmacology?RichardJAll
2、enandTimothyCElston-State--timespectrumofsignaltransductionlogicmodelsViewthearticleonlineforupdatesandenhancements.AidanMacNamara,CamilleTerfve,DavidHenriquesetal.Recentcitations-Emergingwhole-cellmodelingprinciplesandmethodsArthurPGoldbergetal-DynamicInfluenceNetworksfor
3、Rule-BasedModelsAngusG.Forbesetal-LitPathExplorer:aconfidence-basedvisualtextanalyticstoolforexploringliterature-enrichedpathwaymodelsAxelJSotoetalThiscontentwasdownloadedfromIPaddress61.174.132.238on15/08/2018at06:11Phys.Biol.12(2015)045008doi:10.1088/1478-3975/12/4/04500
4、8PAPERDARPAʼsBigMechanismprogramOPENACCESSPaulRCohenRECEIVEDDefenseAdvancedResearchProjectsAgency(DARPA)7November2014E-mail:paulrcohen@gmail.comREVISED21April2015Keywords:signalingpathways,machinereading,biocuration,informationextraction,artificialintelligence,modeling,syst
5、emsbiologyACCEPTEDFORPUBLICATION5May2015PUBLISHED15July2015AbstractReductionistscienceproducescausalmodelsofsmallfragmentsofcomplicatedsystems.CausalContentfromthisworkmodelsofentiresystemscanbehardtoconstructbecausewhatisknownofthemisdistributedacrossmaybeusedundertheterm
6、softheCreativeavastamountofliterature.TheBigMechanismprogramaimstohavemachinesreadtheliteratureCommonsAttribution3.0licence.andassemblethecausalfragmentsfoundinindividualpapersintohugecausalmodels,automatically.AnyfurtherdistributionofThecurrentdomainoftheprogramiscellsign
7、allingassociatedwithRas-drivencancers.thisworkmustmaintainattributiontotheauthor(s)andthetitleofthework,journalcitationWhenitcomestocomplicatedsystemssuchasthe[2,8,41,52,54,55,63]);whileitdevelopsrepresenta-andDOI.climate,andeconomic,ecologicalandbiologicaltionsandinferenc
8、emethodsformechanisticbiologi-systems,ourinfluencerunsaheadofourunderstand-calmodels,metho
