资源描述：
《血清VEGF、血清VEGF、OPN浓度与进展期胃癌术后复发关系的临床研究.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、血清VEGF、OPN浓度与进展期胃癌术后复发关系的临床研究咸宁市屮心医院同济咸宁医院肝胆胰胃肠外科尹小平黎蔚浩朱栋良王代宏王伟王芳元*摘要：目的研究进展期胃癌患者血清屮血管内皮牛长因子（VEGF）及骨桥蛋白（OPN）浓度与进展期胃癌术后复发的关系，以探讨其作为进展期胃癌术后复发筛查标记物的价值。方法采用酶联免疫吸附试验法（ELISA）检测术前及术后不同吋期40名进展期胃癌患者血清J'VEGF.OPN浓度，观察其阳性率、表现阳性的吋间与术后复发的关系，并与CEA、CA199及影像学检查相比较。结果进展期胃癌根治术后血清VEGF、OPN浓度及阳性率明显下降，与术前比较其
2、差异有统计学意义（啟0.05）；术后转移或复发患者血清VEGF、OPN浓度及阳性率再次升高，与术后一月对比差异有明显统计学意义（P<0.01）；术后复发患者VEGF、OPN浓度及阳性率明显高于未复发者，差异有明显统计学意义JP<0.01）；术前及术后复发吋VEGF、OPN单独检测阳性率高于CEA、CA199,其表现阳性的吋间亦早于CEA、CA199,其差异均有统计学意义（PV0.05）,联合检测吋前者亦高于后者，其差异均有统计学意义（戶<0.05）；血清VEGF、OPN浓度升高表现阳性的吋间明显早于胃镜、CT等影像学检查，其差异有统计学意义（PV0.05）。结论进展
3、期胃癌患者血清VEGF、OPN主要由肿瘤组织分泌产牛，术后监测其血清浓度可用于早期预测和发现肿瘤的转移复发。关键词：血管内皮牛长因子；骨桥蛋白；进展期胃癌；复发ClinicalstudyabouttherelationshipofserumlevelsofVEGF,OPNandtherecurrenceofadvancedgastriccancerYINXiao-ping（LIWei-haoZHUDong-liangWANGDai-hongWANGWei）.DepartmentofGastrointestinalHepatobiliaryandPancreaticS
4、urgery,XianningCenterHospital,Hubei437100,China.*Correspondingauthor:WANGFang-yuan(DepartmentofGastrointestinalHepatobiliaryandPancreaticSurgery,XianningCenterHospital,Hubei437100,China.)Abstract:ObjectiveToresearchtherelationshipofserumlevelsofVEGF、OPNandtherecurreneeofadvancedgastric
5、cancer^anddiscussthevalueofVEGFandOPNasabiomarkertotherecurrenceofadvancedgastriccancer.MethodWedetected40advancedgastriccancerpatients'serumVEGF,OPNconcentrationbeforeandafteroperationbythewayofenzyme-linkedimmunosorbentassay(ELISA).Thenweanalyzedtherelationshipbetweentheirpositiverat
6、es,thetimetheshowpositiveperformaneeandtherecurreneeafteroperations,andcomparedwithCEA,CAI99andimagingexamination.ResultComparedwiththepreoperativelevels,theconcentrationandpositiverateofVEGFandOPNdecreasedobviously,andthedifferencehasstatisticallysignificant(p<0.05).Comparedwiththetim
7、eonemonthafteroperation,theconcentrationandpositiverateofVEGFandOPNriseagain,tothosepatientswhosuffermetastasisorrecurreneeafteroperation,andthedifferencehasstatisticallysignificant(p<0.01).Comparedwiththosepatientswhodidnotsuffermetastasisorrecurrence5patients$concentrationandpositi
