阴性淋巴结数目对胃癌手术患者预后的影响.pdf

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1、·3632·现代预防医学2014年第41卷第19期ModemPreventiveMedicine，2014，Vo1．41，NO．19·临床与预防·阴性淋巴结数目对胃癌手术患者预后的影响易伟，钱洪军，陈帆解放军第九四医院普外科，江西南昌330002摘要：目的探讨阴性淋巴结数目对胃癌手术患者预后的影响。方法回顾性分析2006年1月一2009年9月有完整随访资料的203例胃癌手术患者的临床资料，分别对影响肿瘤复发及术后生存时间的预后因素进行单因素及多因素分析。结果203例胃癌手术患者的总体复发率为34．98％，总体3年生存率为71．92％。单因素分析显示更少的阴性淋巴结数目(<10枚)是影

2、响胃癌患者术后复发及生存时间的显著危险因素(P

3、impactofthenumberofnegativelymphnodesingastriccancerpatientsaftercurativegastrectomyYIWei，QIANHong~Ha，CHENFanDepartmentofGeneralSurgery,the94MilitaryHospitaloftheChinesePeopleLiberationArmy,Nanchang,Jiangxi330002，ChinaAbstract：ObjectiveToinvestigatetheprognosticimpactofthenumberofnegativelymphn

4、odesingastriccanceraftercurativegastreetomy．MethodsThisstudyinvolved203patientswithgastriccancer，whounderwentcurativegastrectomywithcompletefollow-updatafromJanuary2006toSeptember2009．Factorswhichinfluencedtumorrecurrenceandoverallsurvivaltimewereevaluatedbyunivariateandmultivariateanalysis．Res

5、ultsTherecurrencerateof203patientswithgastriccancerwas34．98％，andthe3-yearoveralsurvivalratewas71．92％．Onunivariateanalysis，thefewernegativelymphnodes(<10)hadastatisticallysignificantnegativeimpactontumorrecurenceandoverallsurvivaltime(尸0．01)．Multivariateanalysisshowedthattumorsize，tumordiferenti

6、ation，depthofinvasion，thenumberofpositivelymphnodes，andthenumberofnegativelymphnodeswereindependentpredictorsoftumorrecurrenceandoverallsurvivaltime．Stratifiedanalysisrevealedthatthefewernegativelymphnodes(<1o)hadastatisticallysignificantnegativeimpactonoverallsurvivaltime(尸≮0．01)ingastriccance

7、rpatientswithstageIII．ConclusionInsuficientnumberofnegativelymphnodesisanindependentriskfactoraffectingtheprognosisofpatientswithgastriccancerundergoingcurativegastrectomy．Morelymphnodesshouldbereseetedtoinsuresuficientnumberofneg