多发性骨髓瘤MRI骨髓浸润模式与血管生成关系的研究.pdf

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1、·2436·孙忠亮，等多发性骨髓瘤MRI骨髓浸润模式与血管生成关系的研究(2)：213—219．[J]．ThrombRes，2011，127(5)：406—410．YanagitaniN，HoriikeA，KudoK，eta1．Acaseofadenocarcinoma[14]CouturaudF．Theoptimaldurationofanticoagulanttreatmentfol—ofthelungwithapulmonarythromboembolismwhichimprovedlowingpulmonaryembolism[J]．RevMalRespir，2011，28(10)：w

2、ithgefitinib[J]．NihonKokyukiGakkaiZasshi，2011，49(4)：1265—1277．282—286．[15]MenapaceLA，KhoranaAA．Theroleofthromboprophylaxisin[12]GaliotoNJ，DanleyDL，VanMaanenRJ．Recurrentvenousthmm—cancerpatients：emergingdata[J]．CurOpinHematol，2010，17boembolism[J]．AmFamPhysician，2011，83(3)：293—300．(5)：450—456．[13]Spir

3、kD，BanyaiM，JacomellaV，eta1．Outpatientmanagementof(编校：闫沛)acutedeepveinthrombosis：resultsfromtheOTIS—DVTregistry．．．造血器·淋巴系肿瘤．．．多发性骨髓瘤MRI骨髓浸润模式与血管生成关系的研究孙忠亮，孙道萍，贾焕香StudyofthecorrelationbetweenMRIpatternsofmarrowinvolvementandangiogenesisinmyelomaSunZhongliang，SunDaoping，JiaHuanxiangTheFirstPeoplesHospi

4、talofJining，Shandongfining272011，China．【Abstract】Objective：ToexplorecorrelationsbetweenMRIpatternsofmarrowinvolvementandbonemarrowan．giogenesisinmyeloma．Methods：Twenty—fivenewlydiagnosedmyelomapatientswereenrolledinthisstudy．Thelevelofserumcreatinine，albumin，132一micoglobulin，andLactateDehydrogenasew

5、ereroutinelydetected．Thepres—enceofboneinvolvementwasdocumentedwithconventionalskeletalsurveys．Durie—Salmonstagingsystemwas印-pliedforstaging．SpinalmarrowwereexaminedwithMRimaging．T1一weightedimages(T1WI)，shortTIinversionre—covery(STIR)andenhancedT1w1wereperformedandanalyzedforpatternsofmyelomatousinv

6、olvement．10pair—ientswithnon—malignanthemotopoieticdiaseaseswereenrolledinthecontrolgroup，whosebonemarrowwereap—provedtobenotinvolvedthroughbonemarrowsmearandbiopsy．Microvesseldensity(MVD)wasdeterminedbyim—munohistochemicalidentificationofmicrovascularendothelialcellsinthebonemarowtrephinebiopsiesus

7、ingahu-manmonoclonalantibodyagainstCD34．Inaddition，Anenzyme—linkedimmunosorbentassaywasusedforthedetec-tionoftheserumvascularendothelialgrowthfactor(VEGF)．Results：TheserumlevelsofVEGFandMVDinbonemarro