控制昼夜节律的分子机制.ppt

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1、First,twoquestions.Whendoyougetup?Whendoyougotobed?ThebiologicalclockiswarningyouThemolecularmechanismofcontrollingcircadianrhythm控制昼夜节律的分子机制Reporter：ZhangQing2018.06.06Thesunsetbuttherest.（日落而息）Thesunrisemakes.(日出而作)Aphenomenonofthecircadianrhythm/thebiologicalclockHOWDOESI

2、TWORKINGENE?Thefruitfly:sleepsduringthedayhowlsduringthenightWHY?Themutation(缺失)ofaperiodgeneinthebody周期基因HowtoRealizeRegulationofCircadianRhythmprecisly?如何实现昼夜节律的精确调控?WhatIsthePeriodGene?TheperiodgeneencodesaproteincalledPER.ThetimelessgeneencodesaproteincalledTIM.Thedouble

3、-timegeneencodesaproteincalledDBT.ThePERproteinwillbetransferredfromthecytoplasm(细胞质)tothenucleuswiththehelpofTIMproteinatnight.ThePERproteinwilldegrade（降解）duringtheday.Theprocessofaccumulationanddegradationisabout24hours,whichcorrespondstopeople'sdayandnight.DBTistoslowdown

4、theaccumulation（积累）ofPERprotein,whichallowspreciseregulationofcircadianrhythms.Openthelockrequirestwokeys,onecalledthePERproteinandtheothercalledaTIM.Thefrequency(频率)ofopeningthedooriscontrolledbytheDBTprotein.TheprocessislikedasalockandakeyFirst,healsomeofthegeneticdiseases

5、（遗传性疾病）.Second,cureinsomnia(失眠).Third,revealthedangerofstayinguplate.WhatisTheUseofThisFinding?Atlastbutnotatleast,wemustletthebodyrestattherighttime.Payattentiontothebiologicalclock,whoiswarningyou!THANKYOU!