冠状病毒Coronavirusl论文-2017 Impact of Respiratory Virus Infection before Hematopoietic Cell Transplantation (HCT) on Post-Transplant Outcomes i.pdf

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1、Abstracts/BiolBloodMarrowTransplant23(2017)S18–S391S51withamismatchindonor-recipientinheritedciHHV-6statusgroupand10%(37/382)diedinthenot-testedgroup(P=.22).hadincreasedriskforaGVHDgrades2-4(Table1).Identify-Inunivariableanalyses,pre-HCTrespiratoryvirusi

2、nfectioningtheimpactofdualpositivityforinheritedciHHV-6ondidnotnegativelyimpactmortalityinallpatientsandintheoutcomeswaslimitedbysmallnumbers.allogeneicHCTsubset.Among,allogeneicHCTrecipients,Conclusions:ThisisthelargeststudyofoutcomesafterHCTpre-HCTresp

3、iratoryvirusinfectionofindividualviralgroupswithdonorsorrecipientsharboringinheritedciHHV-6.Thesealsodidnotshowanegativeimpactondaysaliveandoutpatientsdidnothavestatisticallysignificantdifferencesinofhospital(meandifferencetoasymptomatic/not-testedpa-over

4、allsurvivalcomparedtoHCTpairswithoutinheritedtients:PCRpositivesymptomatic−1.8,95%CI,−6.1to2.5;ciHHV-6.Donor-recipientmismatchininheritedciHHV-6PCRnegativesymptomatic−3.2,95%CI,−6.9to.5).ResultsstatusincreasedriskforaGVHDgrades2-4.Furtherstudiesremainedn

5、on-significantafteradjustingforothersignifi-areneededtovalidatethesefindingsandidentifypotentialcantriskfactors(stemcellsourceandconditioningregimen).mechanismsleadingtoalloreactivity.Conclusion:Thisstudysuggeststhatcurrentrecommenda-tionstodelayHCTforRSV,H

6、MPV,influenza,adenovirusandPIVareeffective.Thepresenceofpre-transplantHRVandHCoV,forwhichdelayisnotroutinelyrecommended,may44nothaveanegativeimpactontransplantoutcomeinadultImpactofRespiratoryVirusInfectionbeforeHCTrecipients.Furtherdataareneededtodefineth

7、erela-HematopoieticCellTransplantation(HCT)onPost-tivesignificanceofupperversuslowerrespiratorytractviralTransplantOutcomesinAdultsinthePCREra:Doinfections.RhinovirusandCoronavirusInfectionsMatter?Yae-JeanKim1,2,AlpanaWaghmare1,3,4,JaneM.Kuypers5,KeithR.J

8、erome1,5,StevenA.Pergam6,7,8,HuXie1,WendyM.Leisenring1,ChikaraOgimi4,JanetA.Englund3,4,45MichaelJ.Boeckh6,9.1FredHutchinsonCancerResearchMaribavirforTreatmentofCytomegalovirusInfections2DepartmentofPediatrics,SamsungCenter