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Structuralinsightsintotheinteractionofcoronaviruspapain-likeproteasesandinterferon-stimulatedgeneproduct15fromdifferentspeciesCourtneyM.Daczkowski,JohnV.Dzimianski,JozlynR.Clasman,Oc-taviaGoodwin,AndrewD.Mesecar,ScottD.PeganPII:S0022-2836(17)30187-0DOI:doi:10.1016/j.jmb.2017.04
2、.011Reference:YJMBI65390Toappearin:JournalofMolecularBiologyReceiveddate:25January2017Reviseddate:4April2017Accepteddate:18April2017Pleasecitethisarticleas:Daczkowski,C.M.,Dzimianski,J.V.,Clasman,J.R.,Goodwin,O.,Mesecar,A.D.&Pegan,S.D.,Structuralinsightsintotheinteractionofcoronaviruspapain-li
3、keproteasesandinterferon-stimulatedgeneproduct15fromdifferentspecies,JournalofMolecularBiology(2017),doi:10.1016/j.jmb.2017.04.011ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergoco
4、pyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.ACCEPTEDMANUSCRIPTStructuralinsightsintotheinteractionofcoronaviruspapain
5、-likeproteasesandinterferon-stimulatedgeneproduct15fromdifferentspecies1121CourtneyM.Daczkowski,JohnV.Dzimianski,JozlynR.Clasman,OctaviaGoodwin,21AndrewD.Mesecar,ScottD.Pegan*1DepartmentofPharmaceuticalandBiomedicalSciences,UniversityofGeorgia,Athens,Georgia30602,UGA.2DepartmentofBiochemistr
6、y,PurdueUniversity,WestLafayette,USA.Contributedequally.ACCEPTEDMANUSCRIPT*CorrespondenceaddressedtoCollegeofPharmacyUniversityofGeorgia,422PharmacySouth,Athens,GA30602;spegan@uga.edu(SDP);(706)542-34351ACCEPTEDMANUSCRIPTAbstractSevereAcuteandMiddleEastRespiratorysyndromecoronaviruses(SARS-Co
7、VandMERS-CoV)encodemultifunctionalpapain-likeproteases(PLPs)thathavetheabilitytoprocesstheviralpolyproteintofacilitateRNAreplicationaswellasantagonizethehostinnate-immuneresponse.Thelatterfunctioninvolvesreversingpost-translationalmodif
