冠状病毒Coronavirusl论文-2006 PL-2 Structural insights into SARS coronavirus replication machinery(Plenary Lecture,Abstract,Meeting Program of EA.pdf

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1、TheBiophysicalSocietyofJapanGeneralIncorporatedAssociationTheBiophysicalSocietyofJapanGeneralIncorporatedAssociationPL-1ComputationalPL'2StructuralBiologytoUnderstandGenomeandTiranscriptomeinsightsintoSARScoronayirusreplicationmachineryrOMitikoGoOZiheRaoOchanomizui'Tsinghua-Nankai-IBP"Univ

2、.,rointResearchC}ToupForStructuralBio]og.vZiheRaoisgrouphasbccnactivcinSARSbasicresearehsinccthc2003globaloutbreak.andwasthefirsttodeterniinethecrysta1struetureofakeyreplicasepieteinencodeclbytheSARScoronuyhus(SARS-CoV)-themai"proteuseerMpro-anditscomplexwithaninhibitotHisgrouphassincemade

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4、tweentwoSARSnon-stmcturalproteins,nsp7andnspg:thedodecamerstmctureoftheSARSnon-structuralprotcinnsp10:andthchexamcrstructurcoftheMHVnon-structuralprotciniisp15,anendoribonucLcasc,Withinoretham1Sp]'otejnandcomplexsrrucmresfrornSARS-CoVandrelatedcoronavirusestodate.ZiheRao'sgrouphasprovidedi

5、mporta]tstructurutinsightsintocoronuyirusreplicutien/transcriptiun.References/[1]Yftng,H.etal.&Rao,Z.(2ooS).PLoSBiol3,e324.[2]Zhai,Yetal.&Rao,Z.(200S).NatStmeLMolBioll2,9SO-6.r3]Bardam,M.,Yhng.H.&Rao,Z.(2005),CMrrOpinStructBjol15,664-72.1'41Xu,Metal,&Rao,Z,

6、u,lr:ctal,&Rao.Z,(2004),JBio]Chem279,49414-9.L61Xu,Y.etat&Rao,Z.C2004).Biochemisnry43,14064-71.L7]Yang,H.etal.&Ruo,Z.(2003).PrecNuttAeadSciUSA100,13190-5,PL-3ConfOrmationalPL-4BiophysicalPreferencesefProlineResidueandItsDeriyatiyesbasisofcellelectroporationwithimplicationstoCYeungKeeKangim

7、proyementofcancerradiotherapyDept.ofChemistry,ChungbukNatl.Uniy.OKaushalaPrasadMishTaRadiationBiologyDivision,BhabhaAtomicResearchCentreWereportheretheresllltgonAc-X-NHMe(X=Pro,Hyp,Oxa,Aze,undMp)andoligopro1ines(Ac-(Pro).-NMeq.n=1teS)asmodeisfortheprelineresid