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1、5354_07_p528-53412/6/042:31PMPage528VIRALIMMUNOLOGYVolume17,Number4,2004©MaryAnnLiebert,Inc.Pp.528–534Structure-BasedPreliminaryAnalysisofImmunityandVirulenceofSARSCoronavirusYANLI,1,2*CHUNQINGLUO,1*WEILI,1ZHAOXU,1CHANGQINGZENG,1SHENLIBI,3JUNYU,1JUNWU,2andHUANMINGYANG1ABSTRACTTheresea
2、rchonSARS-associatedcoronavirus(SARS-CoV)hasnotstoppedsinceitsdiscovery,butthepathogenesisofSARSisstillunclear.Toexplorethepossiblemolecularmechanismsofthein-vasionandvirulenceofSARS-CoV,weinvestigatedthestructuralbasisoftheviralproteinsusingcomputationalbiology.Forty-fivemotifsrelati
3、ngtosuperantigens,toxinsandotherbioactivemol-eculesweredetectedintheproteinsofSARS-CoV.Theresultsshowedthatthedistributionofthemotifsvariedindifferentproteins.Enzyme-likemotifswerelocatedintheRprotein,whileICAM-1–likeandtoxin-likemoleculeswerelocatedinthespike,envelop,nucleocapsid,PUP
4、1,PUP2andPUP4proteins.ComparisonofSARS-CoVwithotherviruses(OC43,PEDV,HRSV,HHerpVandHAdenoV)showedthateachgroupofmotifswasdifferentforeachtypeofvirus.DatasuggestthattheproteinsofSARS-CoVwithtoxicmotifsmightplaycrucialrolesintargetinghostcellsandin-terferingwiththeimmunesystem.Thisstudy
5、providesnewinformationfordrugandvaccinede-sign,aswellastherapeuticstrategiesagainstSARS.INTRODUCTIONinvestigation,thepathologicalchangeswerecharacter-izedbymassiveinfiltrationandmarkedalveolaredemaHESEVEREACUTERESPIRATORYSYNDROME(SARS),withhemorrhageandhyalinemembraneformation,evenTwi
6、thhighratesofmorbidityandmortality,hasaf-atrophyoflymphandwidelyangitis,butfewinflamma-fectedthousandsofpeopleandkilledhundredsofthemtorycellswereobserved.Furthermore,theserologicalev-sinceNovemberof2002.TheSARS-associatedcoron-idenceshowedanincreasedlevelofIgGatthesecondavirus(SARS-C
7、oV)wasfirstidentifiedasthepathogenweekafteronsetofthesymptoms(12,15).ButtheresultsofthisdiseaseinApril2003(3,6).offlowcytometrydemonstratedbothCD4andCD8ThemostcommonsymptomsofthediseasewerefeverTcellssignificantlydecreasedandwouldrecoverassoon(38.5°C),drycough,myalgia,shortbreath,a
8、nddys
