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1、JVetDiagnInvest3:293-296(1991)SerologicevidenceofcoronavirusinfectioninNewYorkandNewEnglanddairycattlewithwinterdysenteryH.J.VanKruiningen,V.P.Castellano,A.Torres,R.L.SharpeeAbstract.Acuteandconvalescentserawerecollectedfrom8dairyherdswithclassicclinicalfeaturesofwinterdysentery.Anenzy
2、me-linkedimmunosorbentassaywasusedtomeasurecoronavirusantibodytiters,employingcalfdiarrheacoronavirusasantigen.Twenty-twoofthe35animalstested(63%)showeda≥4-foldseroconversion.Adultcattleinall8herdsseroconverted.Thesefindingscomplementpreviouslyreportedimmunoperoxidaseandelectronmicrosc
3、opicevidence,suggestinganetiologicroleforanentericcoronavirusinthisdisease.WinterdysenteryisanacuteintestinaldisorderofandBelgiumreportedcoronavirus-likeagentsorco-adultcattle,particularlydairycattle,inthenorthernronavirusinthefecesofadultcattlewith“epizootic112,6,10UnitedStates.Thedis
4、easeoccursinepizooticpro-diarrhea”and“winterdysentery.”Canadianwork-portionsfromNovembertoMarchandishighlycon-ers,however,reportedfindingcoronavirusantigen,tagiouswithinafarmorcommunity.Insusceptiblemostlyintheformofimmunecomplexes,inthefeces4herds,alloftheadultsareaffectedwithin48hour
5、s,of70%ofnormalcows.AreportfromColoradodoc-periparturientheifers2-4yearsofagearethemostumentedahighincidenceofsheddingofcoronavirussusceptible,andcalves<9monthsoldareunaffected.particlesinthefecesofnormaldairycattleduringthe3Theillnessischaracterizedbyseverediarrhea,whichwinterstabling
6、season.Japaneseinvestigatorsisolatedisoftenbloodtingedorblackandhasacharacteristicacoronavirus-likeagentfromthefecesof1cowwithodor,severedecreaseinmilkproduction,variablede-diarrheaanddemonstratedhemagglutination-inhibi-pressionandanorexia,andsometimesamildcough.tionseroconversiontoref
7、erencestrainsofbovineco-10Fever,leukocytosis,andleukopeniaarenotablyabsentronavirusin59%ofanimalswithepizooticdiarrhea.atthetimeofdiarrhea.ThediseaseisworldwideinOverthepastseveralwinters,wehavedocumenteddistributionandhasbeentransmittedbyfecesorfecalrisesinserumenzyme-linkedimmunoso
