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1、SPECIALTOPICSEditor'sNoteAlthoughSevereAcuteRespiratorySyndrome(SARS)situationhasbeenbroughtundereffectivecontrolaroundtheworld,thiscontagiousdiseasethatcausedawfulterrorandharmstillremainsamystery.Wheredoesthepathogencome?Howarepeopleinfectedwiththedisease?Howdoesthediseasespreadamongp
2、eople?WhatisthepathogenesisofSARS?Therearemanythingsthatneedtobeunder•stood.WiththoroughandbroadinvestigationsonSARSvirus,thescientistsinChinaaregainingmoreandmorescientificachievements.ChineseScienceBulletin,anacademicjournal,hasanobligationtotimelycommunicatetheseachievementstoresearc
3、hersinChinaandabroad.Fromthisissue,wewillcollectivelypublishtherecentlyacceptedcontributionsonSARSvirusresearchinanewcolumncalled"SpecialTopics"andhopeitmayhelppromotetherelevantresearches.ThelatestSARS-relatedresultsinthisissuecomefromfourarticles:ShiRongetal.designedandadopted60meroli
4、gonucleotidemicroarraytodetectSARSvirus,providinganewmethodforquickandearlySARSdiagnosis;GaoLeietal.andQiZhenetal.studiedtheoriginandevolutionofSARScoronavirusbydifferentmethodsanddrewsomeenlighteningconclusions;JiaGuangleetal.introducedthethreezoonosescausedbyfruitbats,whichmaygiveanin
5、spirationtoSARSepidemiologicalinvestigation.ChineseScienceBulletin2003Vol.48No.121165-1169Keywords:SARScoronavirus,oligonucleotidemicroarray,RDtech•nique,fluorescentlabeling,molecularhybridization.DesignandapplicationofDOl:10.1360/03wc021660meroligonucleotideInApril2003,anovelcoronavims
6、[I,2]whichwasmicroarrayinSARSassociatedwithcasesofSevereAcuteRespiratorySyn•drome(SARS)wasfirstisolatedandsequencedinCanada.coronavirusdetectionThegenomeofSARScoronavims(SARS-CoV)is29727[3]nucleotidesinlengthandhas11knownopen111SHIRang1,MAWenli,WUQinghua,ZHANGBaa,readingframes(ORFs).Alt
7、houghthegenomeorganiza•1SONGYanbin1,GUOQiuye1,XIAOWeiwei,tionofthisvimsissimilartothatofothercoronavimses,2WANGYan1&ZHENGWenlingphylogeneticanalysesandsequencealignmentshowthatSARS-CoVisnotcloselyrelatedtoanyofthepreviously1.InstituteofMolecularBiology,FirstMilitaryMedicalUnive
