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1、肝功能实验室检查ContentsofLiverFunctionTestProteinMetabolismBilirubinMetabolismBileAcidMetabolismLipidMetabolismRelatedSerumEnzymesExtractionandExcretion物质代谢、合成生物转化分泌排泄糖、蛋白质、脂质激素、维生素……储存能量ProteinMetabolismBilirubinMetabolismRelatedSerumEnzymesProteinMetabolism:SynthesisandStoragefuncti
2、onSerumTotalProtein,albuminandglobulinSerumProteinElectrophoresisSerumPrealbumin血清总蛋白STP，serumtotalprotein血清中所含各种蛋白的总称STPAlbuminGlobulinα1α2βothersγFromLymphocytesandplasmacyteSynthesisinLiverSerumProteinTP(serumtotalprotein)includingalbuminandglobulinReferencevalue:TP60-80g/LA
3、lb40-50g/LGlo20-30g/LA/Gratio1.5-2.5:1TotalProtein>80g/LHyperproteinemiaSeealsoGlobulin>35g/L,especiallyinγ-globulinhypovolemia：e.g.Severediarrhea,vomit,highfever、shock<60g/LHypoproteinemiaSeealsoalbumin<25g/Lhypervolemia:e.g.water-sodiumretention清蛋白（albumin,Alb）又称为白蛋白majorprot
4、eininserum,≈60%Half-life:15-19daysSynthesisinLiverFunction：MaintainplasmaosmoticpressuretransportnutritionClinicalsignificance:Alb<25g/LSynthesisdecreaseinliver：damageoflivercellsChronicliverdiseasee.g.hepatitis,livercirrhosis,livercancerMasslose：nephroticsyndrome,severeburn,ac
5、uteorseverehemorrhageConsumptionincreased：chronicconsumptivediseasee.g.SeriousTuberculosis,malignanttumor,hyperthyroidismClinicalsignificance:Alb↓Malnutrition:hypoalbuminemiaNormal:>35g/LMild:28-34g/LModerate:21-27g/LSevere:<21g/LEdema球蛋白(globulin，Glo)STP-A=Gmadeupofdifferentpr
6、oteinscalledalpha,beta,andgammatypesSomearemadebytheliver,whileothersaremadebytheimmunesystem（γ-globulin)参考值：G20-30g/LClinicalsignificance:Globulin↑ChronicliverdiseaseM-proteinemiaMultipleMyeloma,MalignantLymphoma,MacroglobulinemiaAutoimmunedisease：SLE,rheumaticfever,rheumatoid
7、arthritisChronicinflammationorinfections:tuberculosis,malaria,schistosomiasisClinicalsignificance:Globulin↓Physiological↓：infantsImmunosuppressivestatelong-termtreatmentwithglucocorticoidorimmunosuppressantsCongenitalgamma-globulinemiaA/G:1.5-2.5:1A/G↓:A↓orG↑Liverfunctiondamage
8、Alb<30g/Lorreverse:poorprognosisAlb>30g/L:betterprogos
