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ID:50229636
大小:426.00 KB
页数:36页
时间:2020-03-07
《重度OSAHS患者CPAP治疗和手术治疗后血清S100β蛋白水平变化及意义.doc》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、的紊乱,提高患者的记忆力和认知功能进而提高患者的生活质量。关键词重度阻塞性睡眠呼吸暂停低通气综合征;S100B蛋认知功能;记忆力AbstractObjectives:Understandthesevereobstructivesleepapneahypopneasyndrom(OSAIIS)patientsserumaccordingtoS100PproteinlevelsandMoCAscores;ObserveCPAPandsevereOSAIISpatientsaftersurgicaltreatmentserumaccord
2、ingtoS100BproteinlevelsandMoCAscoreschange;AnalysisofthesevereOSAHSpatientsserumaccordingtoS100PproteinlevelsandthecorrelationofMoCAscore;AssessmentisgivenprioritytowiththeoperationofthecomprehensivetreatmentinpatientswithsevereOSAHS,thendiscussesthemolecularmechanisms
3、ofsevereOSAHSpatientscognitivedecline.Method:Choose100age<60yearsoldthroughPSGmonitoringanddiagnosisforpatientswithsevereOSAHS,Thenextday,CPAPtherapyinsevendaysafteradmission,comprehensivetreatmentafter3monthsfollow-uptodeterminetheserumaccordingtoS100Pprotein1evels,Mo
4、CAscoreatthesametime.AssessmentofsevereOSAHSpatientsserumaccordingtoS1000proteinlevelsandMoCAscoresituation,comparingthreegroupsaccordingtoserumS100Bprotein1evelchangeandchangesofthreegroupsofMoCAscore.SerumaccordingtoS100Bproteindetectionexperimentenzyme1inkedimmunoso
5、rbent(ELTSA)method.Results:1.SevereOSAHSpatientsserumaccordingtoS100PproteinlevelwaspositivelycorrelatedwithAHI,andshowedanegativecorrelationwiththelowestbloodoxygensaturation(LSaO2);2.PatientswithsevereOSAHSMoCAscorehassignificantnegativecorrelationwithAHI,andhassigni
6、ficantpositiverelatedwiththelowestoxygensaturation(LSaO2);3.AccordingtoS100BproteinlevelsandnegativelycorrelatedwithMoCAscore;4.SerumaccordingtoS100PproteinlevelsinCPAPtreatmentthereisadecreaseinthesevendayslater,onadmissionandcomparethedifferencewasstatistickilysignif
7、icant(P<0.05),Comprehensivetreatmentafter3monthsfollow-up,serumaccordingtoS100Pproteinlevelssignificantlydecreased,comparedwithonadmissionandsevendaysafterCPAPtreatmentdifferencesstatisticallysignificant(P<0.05);5.CPAPtreatmentforsevendaysMoCAscoreincreasedslightly,the
8、rewasnostatisticallysignificantdifferencecomparedwithonadmission(P>0.05),Comprehensivetreatmentafter3monthsfollow-up,
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