重度OSAHS患者CPAP治疗和手术治疗后血清S100β蛋白水平变化及意义.doc

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1、的紊乱，提高患者的记忆力和认知功能进而提高患者的生活质量。关键词重度阻塞性睡眠呼吸暂停低通气综合征；S100B蛋认知功能；记忆力AbstractObjectives：Understandthesevereobstructivesleepapneahypopneasyndrom(OSAIIS)patientsserumaccordingtoS100PproteinlevelsandMoCAscores；ObserveCPAPandsevereOSAIISpatientsaftersurgicaltreatmentserumaccord

2、ingtoS100BproteinlevelsandMoCAscoreschange;AnalysisofthesevereOSAHSpatientsserumaccordingtoS100PproteinlevelsandthecorrelationofMoCAscore;AssessmentisgivenprioritytowiththeoperationofthecomprehensivetreatmentinpatientswithsevereOSAHS,thendiscussesthemolecularmechanisms

3、ofsevereOSAHSpatientscognitivedecline.Method：Choose100age<60yearsoldthroughPSGmonitoringanddiagnosisforpatientswithsevereOSAHS,Thenextday,CPAPtherapyinsevendaysafteradmission,comprehensivetreatmentafter3monthsfollow-uptodeterminetheserumaccordingtoS100Pprotein1evels,Mo

4、CAscoreatthesametime.AssessmentofsevereOSAHSpatientsserumaccordingtoS1000proteinlevelsandMoCAscoresituation,comparingthreegroupsaccordingtoserumS100Bprotein1evelchangeandchangesofthreegroupsofMoCAscore.SerumaccordingtoS100Bproteindetectionexperimentenzyme1inkedimmunoso

5、rbent(ELTSA)method.Results：1.SevereOSAHSpatientsserumaccordingtoS100PproteinlevelwaspositivelycorrelatedwithAHI,andshowedanegativecorrelationwiththelowestbloodoxygensaturation(LSaO2);2.PatientswithsevereOSAHSMoCAscorehassignificantnegativecorrelationwithAHI,andhassigni

6、ficantpositiverelatedwiththelowestoxygensaturation(LSaO2);3.AccordingtoS100BproteinlevelsandnegativelycorrelatedwithMoCAscore;4.SerumaccordingtoS100PproteinlevelsinCPAPtreatmentthereisadecreaseinthesevendayslater,onadmissionandcomparethedifferencewasstatistickilysignif

7、icant(P<0.05),Comprehensivetreatmentafter3monthsfollow-up,serumaccordingtoS100Pproteinlevelssignificantlydecreased,comparedwithonadmissionandsevendaysafterCPAPtreatmentdifferencesstatisticallysignificant(P<0.05);5.CPAPtreatmentforsevendaysMoCAscoreincreasedslightly,the

8、rewasnostatisticallysignificantdifferencecomparedwithonadmission(P>0.05)，Comprehensivetreatmentafter3monthsfollow-up,