重度OSAHS患者CPAP治疗和手术治疗后血清S100β蛋白水平变化及意义

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1、忆力和认知功能障碍的原因Z-,综合治疗能改善患者低氧血症、纠正睡眠结构的紊乱，提高患者的记忆力和认知功能进而提高患者的生活质量。关键词重度阻塞性唾眠呼吸暂停低通气综合征；S100P蛋白；认知功能；记忆力AbstractObjectives：Understandthesevereobstruetivesleepcipneeihypopneasyndrom(OSAlIS)patientsserumaccordingtoS100BproteinlevelsandMoCAscores；ObserveCPAPandsevereOSAlISpa

2、tientsaftersurgicaltreatmentserumaccordingtoS100BproteinlevelsandMoCAscoreschange;AnalysisofthesevereOSAHSpatientsserumaccordingtoS1000protein1evelsandthecorrelationofMoCAscore;AssessmentisgivenprioritytowiththeoperationofthecomprehensivetreatmentinpatientswithsevereOS

3、AHS,thendiscussesthemolecularmechanismsofsevereOSAHSpatientscognitivedecline.Method：Choose100age<60yearsoldthroughPSGmonitoringanddiagnosisforpatientswithsevereOSAHS,Thenextday,CPAPtherapyinsevendaysafteradmission,comprehensivetreatmentafter3monthsfollow-uptodeterminet

4、heserumaccordingtoS100Pproteinlevels,MoCAscoreatthesametime.AssessmentofsevereOSAHSpatientsserumaccordingtoS100PproteinlevelsandMoCAscoresituation,comparingthreegroupsaccordingtoserumS100BproteinlevelchangcemdchangesofthrccgroupsofMoCAscore.SerumaccordingtoS100Bprotein

5、detectionexperimentenzymelinkedimmunosorbent(ELTSA)method.Results：1.SevereOSAHSpatientsserumaccordingtoS1003proteinlevelwaspositivelycorrelatedwithAHI,andshowedanegativecorrelationwiththelowestbloodoxygensaturation(LSaO2);2.PatientswithsevereOSAHSMoCAscorehassignifican

6、tnegativecorrelationwithAHT,andhassignifiedntpositiverelatedwiththelowestoxygensaturation(LSci02);3.AccordingtoS100BproteinlevelsandnegativelycorrelatedwithMoCAscore;4.SerumaccordingtoS100BproteinlevelsinCPAPtreatmentthereisadecreaseinthesevendayslater,onadmissionandco

7、mparethediffereneewasstatisticallysignificant(P<0.05),Comprehensivetrcatmentafter3monthsfollow-up,scrumaccordingtoS100Pproteinlevelssignificantlydecreased,comparedwithonadmissionandsevendaysafterCPAPtreatmentdifferencesstatisticallysignificant(P<0.05);5・CPAPtreatmentfo

8、rsevendaysMoCAscoreincreasedslightly,therewasnostatisticallysignificantdifferencecomparedwithonadmission(P>0.05),Comp