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ID:46224594
大小:174.83 KB
页数:34页
时间:2019-11-21
《重度OSAHS患者CPAP治疗和手术治疗后血清S100β蛋白水平变化及意义》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、忆力和认知功能障碍的原因Z-,综合治疗能改善患者低氧血症、纠正睡眠结构的紊乱,提高患者的记忆力和认知功能进而提高患者的生活质量。关键词重度阻塞性唾眠呼吸暂停低通气综合征;S100P蛋白;认知功能;记忆力AbstractObjectives:Understandthesevereobstruetivesleepcipneeihypopneasyndrom(OSAlIS)patientsserumaccordingtoS100BproteinlevelsandMoCAscores;ObserveCPAPandsevereOSAlISpa
2、tientsaftersurgicaltreatmentserumaccordingtoS100BproteinlevelsandMoCAscoreschange;AnalysisofthesevereOSAHSpatientsserumaccordingtoS1000protein1evelsandthecorrelationofMoCAscore;AssessmentisgivenprioritytowiththeoperationofthecomprehensivetreatmentinpatientswithsevereOS
3、AHS,thendiscussesthemolecularmechanismsofsevereOSAHSpatientscognitivedecline.Method:Choose100age<60yearsoldthroughPSGmonitoringanddiagnosisforpatientswithsevereOSAHS,Thenextday,CPAPtherapyinsevendaysafteradmission,comprehensivetreatmentafter3monthsfollow-uptodeterminet
4、heserumaccordingtoS100Pproteinlevels,MoCAscoreatthesametime.AssessmentofsevereOSAHSpatientsserumaccordingtoS100PproteinlevelsandMoCAscoresituation,comparingthreegroupsaccordingtoserumS100BproteinlevelchangcemdchangesofthrccgroupsofMoCAscore.SerumaccordingtoS100Bprotein
5、detectionexperimentenzymelinkedimmunosorbent(ELTSA)method.Results:1.SevereOSAHSpatientsserumaccordingtoS1003proteinlevelwaspositivelycorrelatedwithAHI,andshowedanegativecorrelationwiththelowestbloodoxygensaturation(LSaO2);2.PatientswithsevereOSAHSMoCAscorehassignifican
6、tnegativecorrelationwithAHT,andhassignifiedntpositiverelatedwiththelowestoxygensaturation(LSci02);3.AccordingtoS100BproteinlevelsandnegativelycorrelatedwithMoCAscore;4.SerumaccordingtoS100BproteinlevelsinCPAPtreatmentthereisadecreaseinthesevendayslater,onadmissionandco
7、mparethediffereneewasstatisticallysignificant(P<0.05),Comprehensivetrcatmentafter3monthsfollow-up,scrumaccordingtoS100Pproteinlevelssignificantlydecreased,comparedwithonadmissionandsevendaysafterCPAPtreatmentdifferencesstatisticallysignificant(P<0.05);5・CPAPtreatmentfo
8、rsevendaysMoCAscoreincreasedslightly,therewasnostatisticallysignificantdifferencecomparedwithonadmission(P>0.05),Comp
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