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1、MMP-9WEGF在人喉鳞癌组织中表达及临床［摘要］目的：探讨MMP-9、VEGF在喉鳞癌组织中的表达及临床病理学意义。方法：①免疫组化法检测75例喉癌患者MMP-9及VEGF的表达情况；②利用Spearman秩相关检验分析MMP-9及VEGF的表达与喉癌相关临床参数的关系。结果：®MMP-9表达在声门上型喉癌中与颈淋巴结转移存在正相关(r二0.553,P二0.011),而在声门型喉癌中却无相关性(1-0.219,P=0.382)；VEGF表达在声门上型喉癌中与颈淋巴结转移存在正相关(r二0.362，P二0.018),而在声门型喉癌中却无相关性(r=0.189,P=0
2、.453)；②MMP-9表达与VEGF表达之间存在正相关(r二0.775,P二0.000),且MMP-9表达、VEGF表达均与临床分期、颈淋巴结转移呈正相关("0.468,P=0.003；r二0.402,P二0.012),与年龄等因素无关。结论：MMP-9、VEGF的表达与喉鳞癌的侵袭、颈淋巴结转移有关，两者可能在喉鳞癌的发生、发展中起重要作用。［关键词］喉鳞癌；MMP-9；VEGF；免疫组化［中图分类号］R739.6［文献标识码］A［文章编号］1673-7210(2010)10(b)-012-03Expressionandclinicalsignificanceof
3、MMP-9andVEGFinhumanlaryngealsquamouscellcarcinomaDONGHuileil,GUOXing2*,LIZhendongl(1.DepartmentofHeadandNeckSurgery,LiaoningCancerHospital&Institute,Shenyang110042,China；2.DepartmentofOtolaryngologySurgery,theFirstAffiliatedHospitalofChinaMedicalUniversity,Shenyang110001,China)[Abstract
4、]Objective：ToinvestigatetheexpressionandclinicalsignificanceofMMP-9andVEGFinhumanlaryngealsquamouscellcarcinoma・Methods：MMP-9andVEGFexpressioninsurgicallyresectedtissuesamplesoflaryngealcarcinomas(n二75)wereexaminediinmunohistochemically,andtheircorrelationswithclinicopathologicalfactors
5、wereanalyzed・Results：(DSignificantpositivecorrelationwasrevealedbetweenMMP-9expressionandlymphnodemetastasisinsupraglotticcarcinoma(—0.553,P二0.011),andnocorrelationinglotticcarcinoma(r=0.219,P二0.382)；andsignificantpositivecorrelationwasrevealedbetweenVEGFexpressionandlymphnodemetastasis
6、insupraglotticcarcinoma(r=0.362,P二0.018),andnocorrelationinglotticcarcinoma(r=0.189,P二0.453).②TheexpressionofMMP~9waspositivelycorrelatedwithVEGF(r=0.775,P=0.000),theexpressionsofMMP-9andVEGFwerepositivelycorrelatedwithclinicalstagingoflaryngealcarcinomaandthenecklymphnodemetastasis(r二0
7、.468,P二0.003；r=0.402,P二0.012).Incontrast,thelevelofMMP~9andVEGFexpressionwasnotcorrelatedwithageandsoon.Conclusion：MMP-9andVEGFmayplayanimportantroleinthetumorinvasionandlymphnodalmetastasisoflaryngealsquamouscellcarcinoma・[Keywords]Laryngealsquamouscellcarcinoma；MMP~9；VEGF；Imm
