PTP4A1在食管鳞状细胞癌中的表达及其临床意义的研究.pdf

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1、授予单位代码10089学号或申请号20122347HebeiMedicalUniversityPTP4A1在食管鳞状细胞癌中的表达及其临床意义的研究研究生：朱奇坤导师：王瑞教授专业：外科学二级学院：第四医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师王瑞教授的指导下，由本人独立完成。本学位论文研究所获的研宄成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，实验材料、原始数据、申报的专利等知识产权均归河

2、北医科大学所有。否则，承担柑应的法律责任。年；月？。日河北医科大学研究生学位论文独创性声明木论文是在导师王瑞教授指导下进行的研宄工作及取得的科研成果，论文中除了特别内容加以标注外，文中不含他人己发表或者撰写的科研成果，指导教师对此进行了严格的审查。本研宄论文经由本人独立撰写，文责自负。研宄生签名：导师签章:目录中文摘要················································································1英文摘要·······················

3、·························································4英文缩写················································································7研究论文PTP4A1在食管鳞状细胞癌中的表达及其临床意义的研究前言················································································9材料与方法······

4、·······························································10结果··············································································13附图··············································································16附表·····································

5、·········································19讨论··············································································23结论··············································································25参考文献·························································

6、···············26综述PTP家族分子在肿瘤发生、转移及预后中的作用的研究进展····30致谢····················································································41个人简历··············································································42中文摘要PTP4A1在食管鳞状细胞癌中的表达及其临床意义的研究摘要目的:检测肝细胞再生磷

7、酸因子-1（proteintyrosinephosphatasetypeIVA,member1,PTP4A1）蛋白在食管鳞状细胞癌组织、癌旁组织及正常食管粘膜中的表达情况,分析其表达水平与食管鳞状细胞癌各项临床病理因素的关系,并研究其表达水平对食管鳞状细胞癌术后患者预后的影响。方法:应用组织芯片技术和免疫组化的方法检测155例食管鳞状细胞癌术后患者的癌组织、41例癌旁组织和41例正常食管粘膜中PTP4A1蛋白的表达情况。该组病例均为2004年7月-2014年1月间在河北医科大学第四医院行食管癌根治术的食管鳞状细胞癌患者,均具有完整

8、的临床资料2和随访资料。采用χ检验和等级相关分析来分析PTP4A1蛋白的表达与食管鳞状细胞癌临床病理特征的关系；采用单因素分析（Kaplan-Meier分析）和Cox回归多因素分析来分析PTP4A1蛋白的表达对食管鳞状细胞癌术后患者预后的影响。结果