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1、奥拉西坦联合尼莫地平治疗血管性痴呆的疗效观察［摘要］目的探讨奥拉四坦联合尼莫地平治疗血管性痴呆(VD)的疗效及临床意义。方法将2008年1月〜2010年1月我科收治的80例血管性痴呆患者作为观察对象，随机分为观察组和对照组，乞40例，两组均给予抗血小板、改善脑循环、应用脑保护剂等常规基础治疗。观察组同时给予奥拉西坦注射液4.0g加入生理盐水250皿静滴，1次/d,连用3周。尼莫地平片40mg/次口服,3次/d,连用3周。3周后比较两组的疗效及MMSE评分。结果观察组的总有效率明显高于对照组,差异有显著性(PV0.
2、05)。与治疗前比较,两组的MMSE评分均较治疗前明显增加，差异有显著性(P<0.05)；治疗示与对照纟R相比，观察纟R的MMSE评分增加明显高于对照组，弟异有显著性(PV0.05)。结论奥拉西坦联合尼莫地平治疗血管性痴呆患者有良好的治疗效果，且安全性好，能明显改善虑者的脑功能，值得临床推广。［关键词］血管性痴呆；奥拉西坦；尼莫地平；MMSE评分［中图分类号］R749.13［文献标识码］B［文章编号］1673-9701(2011)35-58-02EfficacyofOxiracetamCombinedwithNi
3、moclipineinTreatmentofVascularDementiaZUOBangqilJIANGChungui21・DepartmentofNeurology,GongqingchengPeople'sHospitalinJiangxiProvince,Jiujiang332020,China；2.DepartmentofPharmacy,GongqingchengPeople'sHospitalinJiangxiProvince,Jiujiang332020,China［Abstract］Object
4、iveToinvestigatetheefficacyandclinicalsignificanceofoxiracetamcombinedwithnimodipineintreatmentofvasculardeinentia(VD).MethodsAll80patientswithVDwererandomlydividedintotwogroups,eachgroup40patients.Twogroupsweregivenanti-platelet,cerebralcirculation,andbasict
5、reatmentroutinecerebralprotectionagents.Observationgroupwasgiventheinjectionoxiracetam4.0g+250mLnormalsalineinfusion,onceaday,for3weeks.Nimodipinetablets40mg/times,3timesadayorally,onceevery3weeks.ComparedtheeffectandMMSEscoreaftertreatment3weeks・ResuItsTheto
6、taleffectiveoftheobservationgroupwassignificantlyhigherthanthecontrolgroup,andthediffereneewassignificant(P<0.05)•Comparedwithbeforetreatment,twogroupsMMSEscorewassignificantlyincreased,andthedifferencewassignificant(P<0.05).Aftertreatmentcomparedwiththecontr
7、olgroup,theMMSEscoreoftheobservationgroupwassignificantlyhigherincreased,andthedifferencewassignificant(P<0・05).ConclusionOxiracetamcombinedwithnimodipineintreatmcntofVDhavegoodtherapeuticeffectandsafety,andcansignificantlyimprovebrainfunctioninpatientswithVD
8、.Ttisworthyofclinicalapplication.［Keywords］Vasculardementia；Oxiracetam；Nimodipine；MMSEscore血管性痴呆(V8SCU1Hdementia,VD)是指由备种脑血管疾病引起的脑损伤而导致的痴呆综合征，临床主要表现为记忆力减退、认知功能缺损、情绪及行为的异常，日前临床治疗方法较多，但疗效报道
