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1、含左氧氟沙星三联疗法治疗幽门螺杆菌阳性残胃炎的疗效观察［摘要］目的评价含左氧氟沙星三联疗法治疗幽门螺杆菌(Helicobacterpylori,Hp)阳性残胃炎患者的疗效。方法将35例Hp阳性的残胃炎患者随机分为两组，治疗纟fl给予埃索美拉哇20mg/次，阿莫西林1000mg/次，左氧氟沙星200mg/次，均为2次/d,连服7d。对照组给予埃索美拉哇20mg/次，阿莫西林1000吨/次，甲硝哇400mg/次，均为2次/d,连服7cL治疗前及停药4周后观察临床症状改善情况、lip清除率，并通过胃镜检查比较残胃黏膜炎症变化。结果治疗组治疗示总有效率为88.89%,较对照组(64.71%
2、)显著提高；Hp清除率治疗纟fl为94.44%,对照纟R为70.59%,差异有统计学意义(P<0.05)；且两纟R症状积分、残胃黏膜炎症活动度差异均有统计学意义(均P<0.05).结论含左氧氟沙星三联疗法对Hp阳性残胃炎患者Hp根除效果明显好于标准三联疗法，Hp根除麻临床症状可显著改善。［关键词］残胃炎；左氧氟沙星；幽门螺杆菌［中图分类号］R573.1［文献标识码］A［文章编号］1673-7210(2012)01(b)-084-03EfficacyofLevofloxacin-basedtripletherapyinpatientswithremnantgastritisofHel
3、icobacterpyloriinfectionLIUYanHUHongsongLIXuefengCHENXiaohongHUANGSuxianHUANGMiaojuanYUHonghuaDepartmentofGastroenterology,thePeople'sHospitalofLonggangDistrictinShenzhenCity,GuangdongProvince,Shenzhen518172,China［Abstract］ObjectiveToobservethetherapeuticeffectsofLevof1oxacin-basedtripletherap
4、yinpatientswithremnantgastritsofHelicobacterpylori(Hp)infection.Methods35pationtswithremriantgastritsofHpinfectionwererandomlydividedinto2groups.18casesoftreatedgroupweretakenEsomeprazole20mgbicl,Amoxicillin1000mgbid,Levofloxacin200mgbid,for7clays;17casesofcontrolgroupweretakenEsomeprazole20mg
5、bid,Amoxicillin1000mgbid,Metronidazole400mgbid,for7days・ThemendmattersofclinicalsymptomsandHperadicationratesbeforetreatmentandaftertreatmcntfor4weekswerecomparedbetweenthetwogroups,andtheinflammationchangesofgastricremnantmucousmembranewerecomparedthroughgastroscope.ResultsThetotaleffectivera
6、teoftreatmentgroupwas88・89%,significantlyhigherthanthecontrolgroup(84.71%),theUperaclicationratewas94.44%inthetreatmentgroupand70・59%inthecontrolgroup,andthereweresignifiedntdifferencesbetweenthetwogroups(P<0・05)・Thedifferencesofsymptomscoresandtheinflemmationmobilityofgastricremnantmucousmemb
7、ranebetweenthetwogroupsweresignificant(P<0.05).ConclusionTheLevofloxacin-basedtripletherapyhasabettereffectforremnantgastritspatientsinHperaclicationthanstandardtripletherapyandthesymptomscanbesignificantlyimprovedafterHperaclication.［K
