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1、动脉溶栓介入治疗急性脑梗死的临床研究作者：陈常胜，王秀春，孙业全,曹贵文单位：261031潍坊医学院附属医院放射科【摘要】目的研究局部注射尿激誨动脉溶栓治疗急性脑梗死的安全性、疗效及预后相关因素。方法对94例发病在24h内的急性脑梗死患者行局部动脉内溶栓治疗。分析血管再通程度、治疗吋间与临床疗效。结果94例屮有效72例(76.6%)』1•管再通程度≥50%67例(71.28%)中有效64例(95.52%),血管再通程度V50%27例(28.72%)中有效8例(29.63%),两者比较差异有显著
2、意义(P<0.05)；发病V6h的48例中有效41例(85.42%),6〜24h的46例中有效31例(67.39%),两者比较差并有显著意义(PV0.05)。发生颅内出血16例(17.02%)。绻局部动脉溶栓治疗急性脑梗死是安全、有效的治疗方法。【关键词】脑梗死，急性：溶栓；尿激酶；介入治疗Clinicalobservationofthetherapeuticeffectoflocalintraarterialthrombolysisinterventiononacutecerebralinfarc
3、tionCHENChangsheng,WANGXiuchun,SUNYequan,etal.DepartmentofRadiology,TheAffiliatedHospitalofWeifangMedicalCollege,Shandong,Weifang261031,China[Abstract]ObjectiveToobservethesafetyandefficacyoflocalintraarterialthrombolysisusingurokinaseinpatientswithacu
4、tecerebralinfarction,andtoanalyzethepredictivefactorsrelatedtotheoutcome.Methods94patientswithacutecerebralinfarctionwhowereatonsetwithin24hoursweretreatedwithlocalintraarterialthromblysisusingurokinase.Angiographicrecanalizationdegree5treatmenttimeand
5、clinicalefficacywereanalyzed.ResultsAmong94patients^effectiveratewas76.6%(72cases);67cases(71.28%)werewithrecanalizationdegree≥50%inwhich64cases(95.52%)hadobviousefficacy;among27cases(28.72%)withrecanalizationdegree<50%,8cases(29.63%)hadobviouseffic
6、acy,therewasasignificantdifferencebetweenthetwogroups(P<0.05).Among48patientswhowereatonsetlessthan6hours,41cases(85.42%)hadefficacy;46patientswhowereatonsetbetween6hoursand24hours,31cases(67.39%)hadefficacy.Therewasasignificantdifferencebetweenthetwog
7、roups(P<0.05).Cerebralhemorrhageoccurredin16patients(17.02%).ConclusionLocalintraarterialthromblysisusingurokinaseisafeasible,effectiveandsafetherapyinthetreatmentofacutecerebralinfarction,whichcanimprovetherecanalizationrateandachievebetterfunctionalr
8、ecovery.【Keywords]Cerebridinfarction,acute;Thrombolysis;Urokinase;Interventiontherapy急性脑梗死(ACI)是山于脑动脉急性闭塞导致的缺血性脑梗死。目前其治疗是尽早消除血栓，促进血管再通，恢复缺血半暗带的供血，抢救濒于死亡的神经细胞，缩小梗死面积，改善预后[1]。局部动脉内溶栓是治疗ACI最有效、最有希望的方法之一。现总结我院应用尿激酶(UK)对ACI进行超选择性动脉溶栓的病例，分析治疗
