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1、动脉溶栓介入治疗急性脑梗死的临床研究作者：陈常胜，王秀春，孙业全,曹贵文单位：261031潍坊医学院附属医院放射科【摘要】目的研究局部注射尿激酶动脉溶栓治疗急性脑梗死的安全性、疗效及预后相关因素。方法対94例发病在24h内的急性脑梗死患者行局部动脉内溶栓治疗。分析血管再通程度、治疗吋间与临床疗效。结果94例中有效72例(76.6%)；•血管再通程度≥50%67例(71.28%)中有效64例(95.52%),血管再通程度V50%27例(28.72%)中有效8例(29.63%),两者比较差异有显著意义(PV0.05)；发病V6h的48例中有效41例(85.42%),6〜
2、24h的46例中有效31例(67.39%),两者比较差异有显著意义(P<0.05)o发牛颅内出血16例(17.02%)池轮局部动脉溶栓治疗急性脑梗死是安全、有效的治疗方法。【关键词】脑梗死，急性；溶栓；尿激酶；介入治疗ClinicalobservationofthetherapeuticeffectoflocalintraarterialthrombolysisinterventiononacutecerebralinfarctionCHENChangsheng,WANGXiuchun,SUNYequan,etal.DepartmentofRadiology,TheAff
3、iliatedHospitalofWeifangMedicalCollege.Shandong,Weifang261031,China【Abstract】ObjectiveToobservethesafetyandefficacyoflocalintraarterialthrombolysisusingurokinaseinpatientswithacutecerebralinfarction,andtoanalyzethepredictivefactorsrelatedtotheoutcome.Methods94patientswithacutecerebralinfa
4、rctionwhowereatonsetwithin24hoursweretreatedwithlocalintraarterialthromblysisusingurokinase.Angiographicrecanalizationdegree,treatmenttimeandclinicalefficacywereanalyzed.ResultsAmong94patients,effectiveratewas76.6%(72cases);67cases(71.28%)werewithrecanalizationdegree≥50%inwhich64cases(
5、95.52%)hadobviousefficacy;among27cases(28.72%)withrecanalizationdegree<50%,8cases(29.63%)hadobviousefficacy,therewasasignificantdifferencebetweenthetwogroups(P<0.()5).Among48patientswhowereatonsetlessthan6hours,41cases(85.42%)hadefficacy;46patientswhowereatonsetbetween6hoursand24hours,31c
6、ases(67.39%)hadefficacy.Therewasasignificantdifferencebetweenthetwogroups(P<0.05).Cerebralhemorrhageoccurredin16patients(17.02%).ConclusionLocalintraarterialthromblysisusingurokinaseisafeasible,effectiveandsafetherapyinthetreatmentofacutecerebralinfarction,whichcanimprovetherecanalization
7、rateandachievebetterfunctionalrecovery.【Keywords］Cerebrialinfarction,acute;Thrombolysis;Urokinase;Interventiontherapy急性脑梗死(ACI)是由于脑动脉急性闭塞导致的缺血性脑梗死。日前其治疗是尽早消除血栓，促进血管再通，恢复缺血半暗带的供血，抢救濒于死亡的神经细胞，缩小梗死而积，改善预后［1］。局部动脉内溶栓是治疗ACI最有效、最有希望的方法么一。现总结我院应用尿激酶(UK)对ACI进行超选择性动脉溶栓的病例，分析
