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1、“AIDS-DEFININGOPPORTUNISTICINFECTIONSANDNEOPLASMS”Table5-11,page125Kumar,Cotran,RobbinsBasicPathologyPROTOZOALANDHELMINTHICINFECTIONS1.Cryptosporidiosisorisosporidiosis:enteritiswithdiarrheaPneumocystosis(pneumoniaanddisseminated)Toxoplasmosis(pneumonia,CNS
2、,heartinfection)CRYPTOSPORIDIOSISPneumocystiscariniipneumoniaPneumocystis:GMSstainToxoplasmosis:heartToxoacutemyocarditisToxocystinheartFUNGALINFECTIONSCandidiasis(thrush/esophagus,trachea,lungCryptococcus(CNS,lung,gut,eye,skin)Coccidioidomycosis(acutedisse
3、minated)Histoplasmosis(acutedisseminated)CandidaalbicansEVERYBODYWITHAIDSGETSCANDIDASTOMATITIS&PHARYNGITIS(THRUSH)ANDESOPHAGITISCandidaalbicansstomatitisCandidastomatitisCandidaesophagitisCryptococcosisDisseminatedacutecoccidioidomycosisDisseminatedacutehis
4、toPASstainMycobacterialdiseasesDisseminatedorextrapulmonaryMycobacteriumavium-intracellulare(MAI)Mtb,pulmonaryorextrapulmonaryMAI-liverMAI:intestineMAI:intestine(acidfaststain)Nocardia:pneumonia,meningitis,disseminatedSalmonella&ShigellaPersistentdiarrheais
5、commoninAIDSCryptosporidiaandIsosporidiacommoncausesbutSalmonellaandShigellaenteritisalsooccurSalmonellabacteremiawithoutanobvioussourceseenwithAIDS:organismmaybeoneofthelesscommonserotypesMycoticaneurysms,boneandjointinfection,lungs,pleura,pericardiumViral
6、infectionsCytomegalovirus(CMV)Pulmonary,intestinal,retinitis,CNSHerpessimples(localized,disseminated)Varicella-zoster,localizedordisseminatedProgressivemultifocalleukoencephalopathy(PML)CMVCMVCMVretinitisHERPESHERPESHerpesinclusions(pneumonia)Progressivemul
7、tifocalleukoencephalopathy(PML)JCvirus(apapovavirus)NorelationshiptoCreutzfeldt-Jacobdz.SlowlyprogressiveInfectsoligodendrogliaInclusionsDemyelinationPML:demyelinationPMLoligodendroglialinclusionPML:bizarreastrocytesNEOPLASMSKaposi’ssarcomaNon-Hodgkin’slymp
8、homas(Burkitt’s,immunoblastic)PrimarybrainlymphomaInvasivecervicalcancerKaposi’ssarcomainAIDSKaposi’sofpalateHHV8andKaposi’sHumanherpesvirus8(HHV-8)iswidelythoughttocauseKS.Elevento20%ofpeoplewhotestne
