miR-101在子宫内膜癌组织中的表达及其与临床病理参数的关系 优先出版.pdf

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1、·436·周飞梅，等miＲ－101在子宫内膜癌组织中的表达及其与临床病理参数的关系XAF1expressionthroughaninterferonregulatoryfactor－1ele-425(214):944－949．mentincoloncancer［J］．Gastroenterology，2006，130(28):747［35］WebberC，GospodarowiczM，SobinLH，etal．ImprovingtheTNM－758．classification:findingsfroma10

2、－yearcontinuousliteraturere-［34］WooYJ，JangKL．All－transretinoicacidactivatesE－cadherinview［J］．IntJCancer，2014，135(14):371－378．expressionviapromoterhypomethylationinthehumancoloncarci-(编校:谈静)nomaHCT116cells［J］．BiochemBiophysＲesCommun，2012，?妇科肿瘤?miＲ－101在子宫内膜癌组

3、织中的表达及其与临床病理参数的关系周飞梅，马晓欣ExpressionofmiＲ－101anditsrelationshipwithclinicalpathologicalparame-tersinendometrialcarcinomaZhouFeimei，MaXiaoxinDepartmentofObstetricsandGynecology，ShengjingHospitalofChinaMedicalUniversity，LiaoningShenyang110004，China．【Abstract】Ob

4、jective:ToinvestigateexpressionofmiＲ－101anditsrelationshipwithclinicalpathologicalparam-etersinendometrialcarcinoma，inordertoexplorethepathogenesisofendometrialcarcinoma，anddiscusstheclinicalsignificanceinthediagnosisandprognosisevaluationofendometrialcarci

5、noma．Methods:Ｒeal－timequantitativere-versetranscriptionpolymerasechainreaction(ＲT－PCＲ)methodwasusedtodetecttheexpressionlevelofmiＲ－101in61casesofendometrialcancertissues．56casesofnormalendometriumtissueswereusedascontrolgroup，toexploretheexpressionandclinic

6、alpathologicaldataofendometrialcarcinoma．Ｒesults:Comparedwiththenormalen-dometrialtissue，expressionofmiＲ－101inendometrialcarcinomawasdown－regulated，withastatisticallysignifi-cantdifference(P＜0．05)．miＲ－101expressionlevelsofdifferentclinicalstages，pathologica

7、lgradesanddepthofmyometrialinvasioninendometrialcarcinomawerecompared，differenceswerestatisticallysignificant(P＜0．05)．AndtheexpressionofmiＲ－101wascomparedindifferentages，lymphaticmetastasis，vascularinvasionanddistantmetastasisofendometrialcarcinomatissuesre

8、spectively，withnostatisticalsignificance(P＞0．05)．Conclusion:Com-paredwiththenormalendometrialtissue，miＲ－101expressionlevelin61casesofendometrialcarcinomatissueweresignificantlydifferent，withstatistical