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时间:2020-02-28
《探讨血清NGAL和Cys-C检测对危重病患者急性肾损伤的临床价值 优先出版.pdf》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、医学理论与实践2017年第30卷第8期Vol.30,No.8,Apr2017JMedTheor&Prac1105探讨血清NGAL和Cys-C检测对危重病患者急性肾损伤的临床价值叶芳红甘肃省陇南市第一人民医院746000摘要目的:探讨血清中性粒细胞明胶酶相关脂质运载蛋白(Neutrophilgelatinaseassociatedlipocalin,NGAL)和胱抑素C(CystatinC,Cys-C)检测对辅助诊断危重病患者急性肾损伤的临床意义,为临床诊治提供参考依据。方法:使用前瞻性研究选择2015年2月-2016年5月本院ICU病房收治的120例危重病患者设为研究组,按照急性肾损伤诊断的
2、RIFLE肌酐标准可将患者分为急性肾损伤组和非急性肾损伤组,分别检测血清NGAL、Cys-C和肌酐(Creatinine,Crea)浓度水平,对结果进行综合分析。结果:患者初入ICU病房时,急性肾损伤组和非急性肾损伤组患者的血清NGAL、Cys-C结果差异无统计学意义(P>0.05),但第24、48和72小时急性肾损伤组患者的血清NGAL、Cys-C结果显著高于非急性肾损伤组,差异具有统计学意义(P<0.05)。急性肾损伤组患者第24、48和72小时检测血清NGAL、Cys-C的阳性检出率均明显高于入ICU即刻,差异具有统计学意义(P<0.05),第24小时联合检测血清NGAL、Cys-C阳
3、性检出率明显高于单项指标阳性检出率,差异具有统计学意义(P<0.05),但入ICU即刻、第48小时和第72小时差异无统计学意义(P>0.05)。结论:血清NGAL、Cys-C指标对危重病患者急性肾损伤早期辅助诊断、病情监测和预后效果判断都有积极的临床意义,联合检测适用于早期肾损伤的筛查,能有效提高患者检出率。关键词中性粒细胞明胶酶相关脂质运载蛋白胱抑素C急性肾损伤危重病中图分类号:R446文献标识码:Adoi:10.19381/j.issn.1001-7585.2017.08.007ToExploretheClinicalSignificanceoftheAcuteKidneyInjuryD
4、iagnosisoftheCriticallyillPatientsbytheNGALandCys-CTestingYEFanghong.TheFirstPeoppe’sHospitalofLongnanCity,GansuProvince746000ABSTRACTObjective:ToexploretheclinicalsignificanceoftheacutekidneyinjurydiagnosisofthecriticallyillpatientsbytheNGALandCys-Ctesting,providingthereferenceforclinicaldiagnosis
5、andtreatment.Methods:Choosing120casesofcriticallyillpatientsfortheexperimentalgroup,accordingtotheRIFLEcreatininestandardfordiagnosisofa-cutekidneyinjurywedividedtheexperimentalgroupintotheacutekidneyinjurygroupandnonacutekidneyinjurygroup,testingtheserumNGAL,Cys-CandCreaconcentrationlevel,analyzet
6、heresultscomprehensively.Results:IntotheICUimmediately,therewerenosignificantlydifferenceofthepatientsweredividedintothesepsisgroupandthenonsepsisgroupshowingthat,therewerenosignificantlydifferenceoftheNGALandCys-Cbetweentheacutekidneyinjurygroupandnonacutekidneyinjurygroup(P>0.05),buttherewassigni
7、ficantlyhigheroftheacutekidneyinjurygroupthanthenonacutekidneyinjurygroupoftheNGALandCys-Cat24thhour,48thhourand72thhour(P<0.05).ThereweremuchhigherofthepositivedetectionrateoftheNGALandCys-Cat24thhour,48th
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