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《贰型糖尿病患者血浆凝血酶-抗凝血酶复合物、纤溶酶-抗纤溶酶复合物的检测及其临床意义.》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、贰型糖尿病患者血浆凝血酶-抗凝血酶复合物、纤溶酶-抗纤溶酶复合物的检测及其临床意义(Detectionandclinicalsignificanceofplasmathrombinantithrombincomplexandplasmin-plasmincomplexinpatientswithtype2diabetesmellitus)Detectionofplasmaantithrombinantithrombincomplexandplasmin-plasmincomplexintype2diabetesmel1itusanditsclinicalsig
2、nificance2010-09-06,SunAihong,ShiLiang,NiZanming,ChenJianqiu,XuXiaofeng,LinWeiOfteninpatientswithdiabetesandchroniccomplicationsofthrombosisandhemostasisfunctionchangeinthrombinandplasmin,intheprocessofbloodcoagulationandfibrinolyticactivitybalanceplaysa.nimportantroleinthrombusform
3、ationinbloodcirculation,theywillsoonbethecombinationofinhibitorinactivated1.Detectionofthrombinandplasmin,respectively,andtheirmajorinhibitors,antithrombinIIIandalpha2~,plasmin,plasmininhibitorformationcomplex(TAT,PAP),canreflecttheamountandrateofformation[2]・Thesensitivityandspecif
4、icityofmonoclonalantibodiesfordetectingTATandPAPinforeigncountriesarebetter・TATandPAPareusedtodetecttheimbalaneeofbloodcoagulationandfibrinolysis,whichisofimportantvalueinthediagnosisofsomethromboembolicdiseases・ThepurposeofthisstudywastodetectthechangesofplasmaTATandPAPinpatientswi
5、thdiabetesmellitusanditsassociatedvasculardiseasesbyELISA,andtoinvestigateitsclinicalsignificanceindiabeticpatients・First,objectsandmethods1.subjects:(1)healthycontrolgroup:20(male9,female11),DepartmentofHuashanhospitalstaffandpartofphysicalexamination,age(54.6+9・1)years(43yearsto78
6、yearsold),bodymassindex(BMI)21.84+1.62.Therewerenoinfectiousdiseases,thrombosis,bleeding,historyofliverandkidneydiseases,andnoChineseandWesternmedicineforthrombosisandhemostasisintwoweeks・(2)type2diabetesgroup:60cases(male31cases,female29cases),allpatientswithtype2diabetes,diagnosti
7、ccriteriaofWHO1985,includingmacroangiopathygroup(DMA)20cases,mainlyreferstothetype2diabetesmellituscomplicatedwithhypertension,cardiovascularandcerebrovasculardiseases:andmicrovasculardiseasegroup(DMI)in20cases,mainlyreferstotheconcurrentrenaldisease,retinopathy;nocomplications(NMD)
8、in20cases・Thesex,ag
