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1、氟马西尼对异丙酚麻醉术后催醒效果探析［摘要］目的探讨异丙酚静脉麻醉后应用氟马西尼的催醒效果和脑电双频指数值的变化及是否可以缩短苏醒和拔管时间。方法采用随机双盲对照法，选行甲状腺择期手术患者60例，年龄30〜60岁，ASAI〜II级。将患者随机分为氟马西尼组(F组)和生理盐水组(N组)，各30例，采用咪达卩坐仑、芬太尼、依托咪酯、顺苯磺酸阿曲库錢复合诱导。术中使用异丙酚和瑞芬太尼复合维持，使BIS值维持在(50±5)之间。待手术伤口皮肤缝合结束后停止泵入异丙酚和瑞芬太尼，之后给予实验用药。F组给予5mL氟马西尼(0.5mg),N组给予等体积生理盐水，分别记录给药
2、前(T0)及给药后1min(T1)、2min(T2)、3min(T3)、4min(T4)、5min(T5)、10min(T6)、15min(T7)后的心率、血压、脉搏血氧饱和度、脑电双频指数，记录用药后清醒时间和拔管时间及术后恶心、呕吐等不良反应。结果两组患者的一般状况比较，差异无统计学意义(P>0.05)。N组和F组从停药到清醒和拔管时间及各个时间点的脑电双频指数值变化差异均无统计学意义(均P>0.05)o结论异丙酚静脉麻醉后给予氟马西尼0.5mg,未发现其能缩短苏醒及拔管时间，也未发现其对BIS值变化有明显影响。［关键词］氟马西尼；静脉麻醉药；异丙酚；脑电
3、双频指数［中图分类号］R614.2［文献标识码］A［文章编号］1673-7210(2012)01(b)-101-03Thereverse-effectaftertheanesthesiaofFlumazenilonPropofolPANNingYUHuanZHANGYuSHAOYanDepartmentofAnesthesiology,theSecondAffiliatedHospitalofDalianMedicalUniversity,LiaoningProvince,Dalian116027,China［Abstract］ObjectiveTodiscu
4、ssthereverse-effectoftheanesthesiaofFlumazenilonPropofolandtheeffectsonthenumberchangesofBIS,andtoexploreifitcanshortenthetimefromanesthesiatoawakeningandextubation・MethodsArandomdouble-blindmethodwasusedon60patients,whowerescheduledforelectivethyroidoperation,aged30-60,ASAgradeITI.
5、ThepatientswererandomlydividedintoFlumazenilgroup(groupF,30cases)andnormalsalinegroup(groupN,30cases).Midazolam,Fentanyl,Etomidateandcis-Atracuriumwereallusedduringtheoperation.PropofolandRemifentanilwereusedintraoperativelyinordertomaintainastablenumberofBISat(50±5)・PropofolandRemi
6、fentanilwerestoppedbeinginjectedaftertheskinincisionwassutrued・Andthentheexperimentalpotionwasgiventothepatients・5mLFlumazenil(0.5mg)wasgiventothegroupFwhile5mLnormalsalinewasgiventothegroupN.Thehearthate,bloodpressure,pulseoximetryandbispecttralindexofeachpatientwererecordedatmulti
7、pietimepoints,before(TO)andaftertheadministrationof1min(Tl),2min(T2),3min(T3),4min(T4),5min(T5),10min(T6),15min(T7)respectively.Meanwhile,theawakeningtimeandextubationtimewererecordedaftertheoperatiori.PostoperativenauseaandvomitingandotheradversereactionswererecordedaswelLResuItsTh
8、erewasnoobviouschan
