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1、带骨膜软骨及不带骨膜软骨自体异位移植实验探究［摘要］目的：通过软骨及带软骨膜软骨在未成年兔中的自体异位移植后变化的研究，为临床选择合适的移植物提供依据。方法：4周家兔12只，将兔的七、八、九肋软骨带骨膜取出，分别分为等长两段。一段保留骨膜，一段去除骨膜，分别埋置于兔的背部两侧对称部位。分别于4、8、12、16周分别取出所埋置的不同组的软骨。将软骨分别观察大体形态、测量长度、作组织学切片行HE染色及电镜观察其显微结构的变化。结果：4周时带骨膜软骨与周围组织结合较去骨膜软骨更紧密，16周与周围组织结合均紧密，两者无明显差异；4周时，两组软骨的长度无显著性差异，8周以后，带骨膜
2、组较不带骨膜组更长(P<0.05)；4〜8周两者均增生活跃，带骨膜比不带骨膜的增生更明显；12周后软骨纤维化明显，增生不明显。结论：幼兔中，带骨膜的软骨较不带骨膜的更适于自体移植。［关键词］自体移植；骨膜；软骨［中图分类号1R622E文献标识码］A［文章编号］1008-6455(2008)06-0864-03TheexperimentalstudyontheautograftcartilageswithperiosteumandwithoutperiosteumZHANGZhi-jial,ZHANGQing-guo2,ZHANGJiaol(DepartmentofPlas
3、ticSurgery,theSoutheastUniversityMedicineCollege,Nanjing210009,Jiangsu,China.2.PlasticSurgeryHospital,ChineseAcademyofMedicalScience,Beijing100041,China)Abstract：ObjectiveTostudythechangesofthecartilagewithandwithouttheperiosteumheterotopictransplantationinbabyrabbit,inordertochooseasuita
4、blegraftforclinicaltransplantatiori.Methodsl2babyrabbitsattheageoffourweeks,eachofthemtheseventh,eighthandninthcostaicartilageswithperiosteumwereremoved,anddividedintotwosegmentsattheevenlength,onesegmentwithperiosteumtheothernon-periosteum.Theywereburiedundertheskinofthebackatbilaterally
5、symmetricalparts・Thedifferentgroupofcartilagesweretookoutat4,8,12,16weeksatrandom・Themorphologyofcartilagewereobservedandtheirlengthweremeasured.TheirHEstaininghistologicalsections,andmicrostruetureundertheelectronmicroscopywereobserved.ResuItsThecartilageswithperiosteumintegratetightlywi
6、thsurroundingtissueatforthweekwhilethecartilageswithoutperiosteumintegratetightlywithsurroundingtissueatsixteenthweekandtherewasnosignificantdifferenceatthattime.Thecellsofcartilagegrowthactivelyatforthandeighthweek,andthosewithperiosteumweremoreactivelythanthatwithoutperiosteal.Theygrowt
7、hednotsoactivelyandhadmorecartilagefibrosisafter12weeks.ConclusionThecartilagewithperiosteumhadmoreadvantagethanthatwithoutperiosteuminautologoustransplantationinbabyrabbits・Keywords：autologoustransplantation；cartilage；periosteum软骨是一种具有弹性的组织，由于其移植后易于成活，是良好的填充、塑形和支持材
