资源描述：
《HPVDNA检测与TCT及阴道镜联合检查在宫颈癌诊断中的应用研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、HPV-DNA检测与TCT及阴道镜联合检查在宫颈癌诊断屮的应用研究摘要目的：探讨高危型人乳头状瘤病毒（HR—HPV）DNA检测与液基细胞学检查（Tc,I，）及阴道镜联合检查在了宫颈病变诊断中的应用价值。方法：对918例患者进行高危型HPV—DNA检测和液基细胞学（Liquid—basedcyto1ogica1test,TCT）检查，对其中一项或两项异常者做阴道镜病理活检，CIN及以上病变为病理阳性，对病理结果阳性患者进行结果分析。采用SPSS13.O统计分析软件，计数资料的比较采用x2检验，以PVO.0
2、5为差异有统计学意义。结果：木研究中检出单独HR—HPV—DNA检测阳性者（H组）为115例，其屮病理结果阳性为39例，符合率为33.9%；单独TCT检测阳性者（T组）为76例，病理结果阳性为40例，符合率为52.6%；HR—HPV—DNA和TCT检测两项均为阳性者（H+T组）是56例，其中病理结果阳性为51例，符合率为91.1%。H组与H+T组比较PVO.0T组与H+T组比较P<0.O,,结果有显著差异。结论：HR—HPV—DNA检测对宫颈病变的敏感度较高，特异性较低，TCT检测特异性较高，而敏感度较
3、低，病理检查结果是诊断的标准，HR—HPV—DNA及TCT与阴道镜联合起来进行检测可以提高宫颈癌及癌1j｛『病变的筛查及早期诊断的检出率。关键词：高危型人乳头瘤状病毒（HR—胛V）DNA检测；薄层液基细胞学检查（TCT）；阴道镜；了宫颈上皮内瘤变（CIN）；宫颈癌（CC）叭Y四2洲0…8州7川5四5肌7,App1•1cationofHPV—DNAdetectingWithTCTtestandColposcopyeXaminationinCerV•1ca1CarcinomaDiagn0sisAbstrac
4、tobjective：TostudyoftheVa1ueofIIPV-1DNAdetectingandTCTcomb■1nedi肖也c01poscopicbiopsyincervicald•1seasesdignosis.Methods：918casesoffema1ereceivedHR.HPV-DNAandTCTdetects,thePositiveresu1tofthedetecti0nswimoneortwohadcolposcopicbiopsyandpatho1ogica1examinati
5、on.C1Nandab0VeareasPatho10gica1positive,ana1ysedthePositiveresu1t.Thenanalysetheresu1twithstatistica1method(SPsS13.0).Resu1ts：In-thestudy,therewere115positivecasesforHR-HPV-DNA(HGr0uP):,with39posit•1VeofpathologicaleXam,coincide.neerateis33.9%；76posit■1V
6、ecasesforTCTtest(TGrouop),州m40p0sitiveofPatho10gica1exam,coincidencerateis52.6%；therewere56casesforb0t11,with51posit•1veofpathologicaleXamcoincideneerateis9l.l%・ComparedwithHGroupandH+TGroup,P<0.01；Comparedwin1TGroupandH+TGroup,P<0・05.ThereWei”esignifica
7、ntdifferencesintheresult.Conclusions：HR一HPV一DNAtesthasahighersensitivityincervical1esions,anda1owerspecificity,TCTtesthasahigherspecificity,butalowersensitivity.Pathologicalexaminationisthediagnost■1ccriteria,thepositiveratecanbera•1sedbyc0mb••in1ngHR--H
8、PV-D：NAandTCTdetects1nscreen•1ngandear1ydiagnos■1s0fcerVica1carcino]maandcervica1precanc翘,0us1esions・Keyword:H1gh—■risk-HumanIpa110mavirus(HR-HPV)IDNAdetect•1ng■♦L•1qu•1d_basedcyto1ogica1test(TCT)■c01P0sc0py•♦cerv•1ca1irit
