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1、17554例宫颈液基细胞学检查结果的临床分析【关键词】宫颈液【摘要】目的通过対宫颈液基薄层细胞学(TCT)检查结果的分析，探讨宫颈阴道细胞学疾病的临床特点。方法冋顾性分析2001〜2003年我院宫颈新柏氏TCT检杏结果。结果17554例TCT中,宫颈阴道细胞学正常2519例(14.35%),且逐年下降。细菌性阴道病1218例(6.939%)o重度炎症659例(3.754%)。低度宫颈上皮内瘤样病变(CIN1)191例(1.088%),发病率逐年上升,分别为0.803%,0.832%,1.44%o高度宫颈上皮内瘤样病变(CIN2/3)50例(0.285%),3年发病率无明显变化。宫颈鳞癌
2、17例(0.097%),宫颈腺癌3例(0.017%),子宫内膜腺癌5例(0.028%)。不典型鳞状细胞(ASCUS)97例(0.553%),发病率逐年降低,分别为0.861%,0.6%,0.37%o人乳头瘤病毒感染(HPV)160例(0.911%),发病率逐年上升为0.717%,0.724%,1」62%;HPV感染在C1N1中占61.78%,感染比例呈逐年上升趋势,但在CIN2/3中仅为12%。CIN1,CIN2/3及宫颈鳞癌的平均发病年龄分别为37.11土&419岁,40.26i9.205岁，45.47±15.34岁;CIN1,CIN2/3,ASCUS及HPV的高发年龄段均为31〜4
3、0岁。结论新柏氏TCT系统提髙了各种宫颈阴道细胞学疾病的检出率及准确性。宫颈阴道细胞学正常比例显著下降，值得担忧。31〜40岁为宫颈癌前病变的高发年龄段，应密切监测。降低HPV感染，治疗并阻止CIN病变升级，是降低宫颈癌发病率的重要环节。HPV感染是CIN1的重要相关因索，但与CIN2/3的相关性尚需进一步研究。关键词液基细胞学宫颈上皮内瘤样病变人乳头瘤病毒Analysisofcenacallesionsdetectedbyliquid-basedpaptest:Astudyofl7554casesLiYe,ShaoShoujin,MengQingwei,etaLDepartmento
4、fObstetricsandGynecoloyg,BeijingHospital,MinistryofPublicHealth,Beijing100730.[Abstract]ObjectiveToanalyzeandevaluatethenewcharacteristicsofcervicallesioninClinics.MethodsToretrospectivelystudythel7554casesofliquid-basedpaptest(ThinPrep)resultsfrom2001〜2003,three-yearperiod.ResultsOftheI7554case
5、s,2519(14.35%)wereWNL,Bacteriavaginitiswasl218(6.939%),severeinfectionwas659(3.754%).C1N1was191(1.088%),meanwhiletheincidenceincreasedfrom2001to2003(0.803%,0.832%,1.44%).CIN2/3was50(0.285%),it，snodifferenceoftheincidenceinthesethreeyears.Squmaouscellcarcinomawas17(0.097%),Glandularcellcarcinoma3
6、(0.017%),Endometrialcarcinoma5(0.028%).97(0.553%)wereASCUS,andtheincidencdecreasedfrom2001to2003(0.861%,0.6%,0.37%).Butl60(0.911%)wereHPVpositive,thisincidenceincreasedobviously(0.717%,0.724%,1.162%)inthreeyears.HPVpositiveinCIN1was61.78%,butitJsonly12%inCIN2/3.TheMeanAgeofCIN1,CIN2/3andSCCwerer
7、e_spectively37.11±8.419,40.26±9.205,45.47±15.34.Thehighincidenceofcervicalcancerprecursorlesions(CIN1,CIN2/3,ASCUSandHPV)wereall31〜40yearsold.ConclusionThinPrepcytologydemonstratedsignifi~cantlyincreasedsensitiv让yandaccuracy
