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1、【摘要】hl的探讨炎性因了在心绞痛发生与发展中的变化及其临床意义。方法将60例经冠状动脉造影检杳确诊为冠心病心绞痛病人分为稳定型心绞痛(SAP)组28例和不稳定型心绞痛(UAP)组32例，采用GC911Y计数仪测定法、免疫散射比浊法测定其血清白细胞介素(IL)6、IL8、肿瘤坏死因子a(TNFa)、高嫩C反应蛋白(hsCRP)水平及外周血白细胞(WBC)数量，并以2()例健康人作为对照纟R。结果与对照组比较，心绞痛病人血清中IL6、IL8、TNFa、hsCRP含量及WBC数均升高(t=2.986〜6.069,P<0.01),且UAP组IL6^
2、IL8、TNFa、hsCRP含量及WBC数高于SAP组(t=2.163〜3.255,Pv0.05、0.01)。UAP组病人的hsCRP与IL6及WBC呈正相关(=0.376、0.366,P<0.05),SAP组病人的hsCRP与WBC呈正相关(=0.515,PvO.Ol)。结论炎症反应参与心绞痛的发生及发展，监测炎性因了水平变化可为临床病悄分级和预后判断提供一定参考。【关键词】心绞痛，不稳定型；白细胞介素6；白细胞介素8；肿瘤坏死因了a；C反应蛋白;白细胞CHANGESANDCLINICALSIGNIFICANCEOFINFLAMMATORY
3、FACTORSINPATIENTSWITHANGINAPECTORISXINGCONGHUI,GUANJUN,WANGXU,etal(DepartmentofCardiology,TheAffiliatedMunicipalHospitalofQingdaoUniversityMedicalCollege,Qingdao266071,China);[ABSTRACT]ObjectiveToexplorethechangesandclinicalsignificanceofinflammatoryfactorsintheoccurrencean
4、ddevelopmentofanginapectoris.MethodsSixtypatientswithcoronaryheartdisease(CHD)accompanyinganginaconfirmedbycoronaryarteriography(CAG),ofwhom,28wereassignedtostableangina(SA)groupand32tounsUibleangina(UA)group.Theseruminterleukin(IL)6,8,tumornecrosisfactora(TNFa),highsensiti
5、vityCreactiveprotein(hsCRP)weremeasuredusingGC911Ycounterassayandimmunescatteringratioturbidimetrictechnique,andwhitebloodcells(WBC)ofperipheralbloodweredetectedaswell.Twentyhealthysubjectsservedascontrols.ResultsComparedwiththecontrols,theserumlevelsofinflammatorycytokines
6、(IL6,IL&TNFa,hsCRP)andWBCinpatientswithanginaelevated(t=2.986-6.069;P<0.01),andthatinpatientsinUAgroupwerehigherthanthoseinSAgroup(t=2.163-3.255;P<0.05,0.01).ThehsCRPandIL6aswellasWBCinUAgroupwerepositivelycorrelated(r=0.376,0.366;P<0.05),andthehsCRPwaspositivelycorrelatedw
7、iththeWBCinSAgroup(r=0.515,P<0.01).ConclusionInflammatoryresponseinvolvesintheoccurrenceanddevelopmentofangina・Amonitoringofthelevelsofinflammatoryindicatorsisofacertainvalueofreferenceforclinicalclassificationandprognosticpredictionofthiscondition.[KEYWORDS]angina,unstable
8、;interleukin6;interleukin8;tumornecrosisfactora;Creactiveprotein;whitebloodcell冠心病
