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1、手术联合放疗在视网膜母细胞瘤治疗中的效果观察【摘要】目的:探讨视网膜母细胞瘤手术联合放疗的临床效果。方法:选取2009年1月-2012年6月的100例视网膜母细胞瘤患者,在患者知情同意的前提下,分为两组,观察组50例在术后均接受放射治疗,对照组50例仅给予常规手术治疗。随访2年以上,统计两组患者1年、2年生存率及复发转移率。结果:两组术后随访24〜60个月,平均随访(43.89±5.39)个月。观察组术后1年生存率为100%,对照组为88%,观察组明显高于对照组,差异具有统计学意义(卩〈0.05)。观察组术后1年复发转移率为2%,对照组为18%,观察组明显低于对照组,差异具有统计学
2、意义(P<0.05)o观察组术后2年生存率为98%,对照组为80%,观察组明显高于对照组,差异具有统计学意义(P〈0・05)。观察组术后2年复发转移率为8%,对照组为24%,观察组明显低于对照组,差异具冇统计学意义(P<0.05)o结论:术后放疗在视网膜母细胞瘤的治疗中起到重要作用,可达到控制肿瘤复发转移、提高生存率的目的。【关键词】视网膜母细胞瘤;放射治疗;手术;临床观察【Abstract]Objective:Toinvestigatetheclinicaleffectofretinoblastomaoperationcombinedwithradiotherapyinthetr
3、eatmentofretinoblastoma・Method:100casesofretinoblastomawereselectedfromJanuary2009toJune2012,uponthepatientsinformedconsent,theyweredividedintotwogroups,50casesintheobservationgroupreceivedradiotherapyafteroperation,50patientsinthecontrolgrouponlyreceivedroutineoperationtherapy.Theywerefollowe
4、dupformorethan2years,1yearsand2yearssurvivalrateandrecurrenceratewerecountedbetweentwogroups・Result:Twogroupswerefollowedupfor24-60months,meanfollow-uptimewere(43.89±5.39)months.The1yearsurvivalratoftheobservationgroupwas100%,1yearsurvivalrateofthecontrolgroupwas88%,theobservationgroupwassigni
5、ficantlyhigherthanthecontrolgroup,thediffereneewasstatisticallysignificant(P<0.05)・The1yearrecurrencerateofthepatientsintheobservationgroupwas2%,1yearrecurrencerateofthecontrolgroupwas18%,theobservationgroupwassignificantlylowerthanthatofthecontrolgroup,thedifferencewasstatisticallysignificant
6、(P〈0.05).The2yearsurvivalrateoftheobservationgroupwas98%,2yearsurvivalrateofthecontrolgroupwas80%,theobservationgroupwassignificantlyhigherthanthecontrolgroup,thedifferencewasstatisticallysignificant(P<0.05).The2yearrecurrencerateofthepatientsintheobservationgroupwas8%,the2yearrecurreneerateof
7、thecontrolgroupwas24%,theobservationgroupwassignificantlylowerthanthatofthecontrolgroup,thediffereneewasstatisticallysignificant(P<0.05).Conclusion:Thepostoperativeradiotherapyinthetreatmentofretinoblastomaplaysanimportanlrole,whichcanc