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1、强光散射网织红细胞参数的实验调杳及临床应用探讨【关键词】参考范围【摘要】tl的通过对LH750型血液分析仪测定的强光散射网织红细胞(HighLaserReticuloyte,HLR)参数做的相关调杏，初步探讨其临床意义。方法调杏80份止常人血液标本，统计其参考范围。调查69份贫血的标本，观察HLR的平均值;观察不同类型贫血的HLR的差异。同时做了网织红细胞成熟度(IRF)的统计分析，观察与HLR的相关情况。结果正常人的HLR的平均值为0.45%(0.17%〜0.73%);贫血标本的HLR的平均值为1.88%;溶贫、急性失血、慢性贫
2、血、白血病和再障各自的HLR的平均值依次为4.05%、1.65%、0.76%、0.42%和0.36%。结论贫血病人的HLR总体高于止常人，反映此时骨髓释入外周血的不成熟的网织红细胞增多，红细胞的牛成加快。不同原因引起的贫血其HLR结果有差异。有骨髓造血机能受抑制的贫血则HLR不增高，甚至低于正常的均值。贫血治疗过程的HLR也有明显的变化。HLR与IRF有一定的相关性(r=0.6806)o调杏结果显示HLR与流式细胞仪检测的高荧光强度网织红细胞(HFR)同样是观察了解血液屮成熟度较低的网织红细胞的参数。临床治疗贫血时观察HLR的变化
3、，比观察网织红细胞计数的变化更加有意义。关键词强光散射网织红细胞(HLR)参考范鬧临床意义InvestigationandclinicalapplicationtheparameterofhighlaserreticuloytebyLH750FeiXuangwentHanLijun,ZhuHongjun,etal.DepartmentofClinicalLaboratary,ShantouCenterHospital,Shantou515031.[Abstract]ObjectiveToinvestigationtheparame
4、terofhighlaserreticuloytebyLH750andstudyitsclinicalsignificance.MethodsConstructedthereferencerangeofHLRbytesting80casesofnormalperson,comparedthediffemceofaverageHLRbytesting69caseswithvarietiesanemia・WehaddonethestatisticalanalysisofIRF,whileanalyzedthecorrelationbe
5、tweenHLRandIRF.ResultsTheaverageHLRofnormalcomparisonwas0.45%(0.17~0.73%),theanemiacaseswas1.88%,andthecaseswithhemolyticanemia,acutehemorrhagetchronicanemia,leukemia,aplasticanemiawereasfollows:4.05%,1.65%,0.76%,0.42%,0.36%.ConclusionTheHLRofanemiaishigherthannormalc
6、omparison,itsindicatedbonemarrowproduceunmaturationreticulocyteincreased,andproductionoferythrocytoaccelerated・ThereweredifferenceofHLRinpatientswithvarietiesanemia,theHLRofanemiawithhematopoiesisdeppressednothigherorlowerthannormalcomparision,andtheHLRhadnotabilitych
7、angeswiththecourseoftreatanemia・TherewerepositivecorrelationsbetweenHLRandIRF(r=0.6806)・Resultsshow:bothHLRandHFRarcpaiameterfortestthematurationratioofreticulocyte,toassaythetransformationofHLRismorevaluablethanreticulocytecountinthecourseofclinicaltreatpatientswitha
8、nemia.Keywordshighlaserreticuloytereferencerangeclinicalapplication强光散射网织红细胞(HighLaserReticuloyte,HLR)是贝克曼一库尔特LH750型等较高档次的血液
