儿童清肺糖浆制备工艺研究

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1、儿童清肺糖浆制备工艺研究［摘要］目的研究儿童清肺糖浆的最佳生产工艺条件。方法对剂型选择、提取工艺路线及制剂工艺技术等方面进行考察。结果儿童清肺糖浆的最佳生产丁艺条件为取处方量橘红、炒紫苏子、紫苏叶、薄荷、前胡、石菖蒲等6味夯加12倍量水浸泡3h后，用水蒸气蒸憾法提取3h,收集挥发油，药液滤过，备用。其余黄苓等16味药加8倍量水提取3次,每次1h,药液滤过。全部药液合并后，减压浓缩至相对密度1.03-1.05（40〜50°C）,放冷，滤过。滤液加入蔗糖600g,山梨酸钾2g,対轻基苯甲酸乙酯0.2g,加热搅拌使溶解，煮沸30min,放冷

2、，滤过。取挥发油用少量乙醇溶解后加入滤液中，充分搅拌，加入纯化水至1000ml,搅拌均匀，分装成瓶，即得。结论优选的儿童清肺糖浆生产工艺，既保证了产品质量，又适合儿童服用，并降低了生产成本，适合于工业化大生产。［关键词］清肺糖浆；正交试验；生产工艺；儿童［中图分类号］R461［文献标识码］A［文章编号］1674-4721(2016)02(b)-0007-04StudyonpreparationtechnologyofChildrentechnologyresearchGUOJin-jial,2DANGXiao-wei3LTJunl,2

3、ZHANGGuang-xingl1.JingfukangPharmaceuticalGroupCompanyLimited,HebeiProvince,Chengde067000,China；2.TheNewExcipientsofTraditionalChineseMedicineEngineeringResearchCenterofHebei,HebeiProvince,Chengde067000,China；3.ChengdeNursingVacationgnalCollege,HebeiProvince,Chengde0670

4、00,China[Abstract]ObjectiveTostudyonoptimumtechnologicalconditionsforClearingLungSyrupforchildren.MethodsTheextractiontechnology,preparationselectionandpharmaceuticaltechnologywerestudied.ResultsThepreparationmethodforClearingLungSyrupforchildreninclusioncomplexwasgotpr

5、escriptionsofdriedtangerinepeel,roastedperi11aseed,foliaperillaeacutae,mint,commonhogfennelroot,rhizomaacorigramineiwiththeamountofwateror12times,andthesoakingtimewas3hthenextractedbywetdistillationfor3h.Volatileoilwascollectedandtheextractionfluidwasfilteredtoreserve.T

6、heother16herbswasextractedthreetimesinwater8times,filtrated,andthefiltratewascombinedwiththeformer.Themixeddecoctionwasconcentratedto1.03~1.05（40〜50°C）,setcold,filtrated,andwasensiledwithsuger600g,potassiumsorbate2gandethylP-Hydroxybenzoate0.2g,heatedandstirred,boiledfo

7、r30min,setcold,filtrated・Volatileoilwasdissolvedbyafewethanolwithefficientstirring,addprovisiontopurifywatervolumeof1000ml,juice,filtering,rebottlingintosmallbottles.ConelusionTheoptimalprocessingconditionnotonlycanensuretheproductqualityanditssuitableforchildrenpatient

8、sbutalsoreducecost.Ttapplytoindustrialproduction.［Keywords］ClearingLungSyrup；Extractiontechnology；Productionpr