低浓度丝裂霉素-C滴眼治疗严重春季角结膜炎的临床观察

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1、低浓度丝裂每索・c滴眼治疗严重春孕角结膜炎的临床观察【关键词】低浓度【摘要】H的观察低浓度丝裂縛素局部滴眼在严車春季角结膜炎患者治疗中的疗效和安全性。方法前瞻、双有、随机、対照临床试验，将40例经皮质类固醇和肥大细胞稳定剂难以治愈的春季角结膜炎病人随机分为用0.02%丝裂霉素・C滴眼的治疗组(n=26)和用熬懾水滴眼的对照组(n=14);治疗2周，每天3次，患者的症状(发痒、流泪、艮光、粘液分泌物、异物感)和体征(结膜充血、上皮点状角膜炎、角膜缘水肿和睑结膜巨大乳头)在入选当天和治疗结束分别记录。结果2周治疗结束吋丝裂霉索・C治疗组的病人

2、比对照组的病人在结膜充血、发痒、畏光、流泪、粘液分泌物、角膜缘水肿等方血明显减轻，差异有统计学意义。结论短期、低浓度丝裂霉素滴眼在对传统治疗无效的严重春季角结膜炎急性期可以考虑应用。关键词低浓度丝裂零素・C严重春季角结膜炎vPstyle=*TEXT-INDENT:24px“align=center>ClinicalobservationofLow-Dos,topicalmitomycin-Cinthetreatmentofseverevervalkeratoco

3、njunctivitsZhaoFang,WangJingming,HeYi.Dept.ofOphthalmology,the2ndHospitalofYulinCity,ShaanxiProv,219000.[Abstract]ObjectiveToobservationtheefficacyandsafetyoflow-dose,topicalmitomycin-cinthetrea

4、tmentofpatientswithseverevernalkeratoconjunctivitis.MethodsAprospective,double-masked,randomized,placebo-controlledclinicaltrial.Fortypatientswithvernalkeratoconjunctivitisrefractorytocombinationofsteroidandmast-cellstabilizertreatmentwererandomlyassigned(2:1)totreatmentw

5、ithtopical0.02%Mitomycin-Ceyedrops(n=26),orplacebo(n=13)threetimesdaily2weeks.Symptoms(itching,tearing,photophobia,mucousdischarge,foreignbodysensation)andsigns(conjunctivalhyperemia,epithelialpunctatekeratitis,limbaledematandpalpebralconjunctivalgiantpapillae)ofvernalcon

6、junctivitisrecordedonthedayofenrollmentandattheendofthetreatmentperiod.ResultsTherewasastatisticalsignificantdecreaseinconjunctivalhyperemia,itching,Photophobiatearing,mucousdischarge,andlimbaledemainthemitomycin-ctreatedgroupcomparedwiththeplacebogroupattheendofthe2weekt

7、reatmentperiod.Conclusionhort-term,low-dose,topicalinitomycin-cmaybecousideredintheacuteexacerbationperiodofpatientswithseverevernalkeratoconjunctivitisrefractorytocouventionaltreatment.KeywordsLow-DoseMitomycin-Cseverevernalkeratoconjunctivitis春季角结膜炎(VKC)是一种主要发生于儿童和青年男性的

8、过敏性眼病[1]。它呈全球流行，波及到所有人种，特别在气候干燥、温度较高的地区发病率明显上升[2]o在春季角结膜炎病人的结膜中发现高浓度的嗜酸细胞，血淸小嗜酸粒细胞增多的情况亦比较多见。泪液中